| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
KLF16 promotes pancreatic adenocarcinoma cell proliferation and migration by positively regulating SMAD6
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Mi, Zhi Zheng, Jiong-Di Lu, Shu-Quan Duan, Jie Zhang, Hai-Qiao Zhang, Yi-Xuan Ding, Jie Yin, Feng Cao, Jun Zhang and Fei Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Municipal Science and Technology Commission |
D171100006517003 |
| Beijing Municipal Administration of Hospitals Incubating Program |
PX2020001 |
| Capital Health Research and Development of Special |
2020-1-2012 |
| the Research Foundation of Beijing Friendship Hospital, Capital Medical University |
Y2018-3 |
|
| Corresponding Author |
Jun Zhang, MD, PhD, Chief Doctor, General Surgery Department, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Xi-Cheng District, Beijing 100050, China, Beijing 100050, China. zhangjun5986@ccmu.edu.cn |
| Key Words |
KLF16; Pancreatic adenocarcinoma; SMAD6; Tumorigenesis; Therapeutic target |
| Core Tip |
Our study provided the evidence that KLF16 acted as an oncogene in pancreatic adenocarcinoma (PAAD). We also identified that SMAD6 served as the downstream substrate of KLF16 and this signaling cascade has never been reported. This mechanism indicated a novel insight into the pathological events during the development of PAAD. |
| Publish Date |
2022-11-15 10:19 |
| Citation |
Mi W, Zheng Z, Lu JD, Duan SQ, Zhang J, Zhang HQ, Ding YX, Yin J, Cao F, Zhang J, Li F. KLF16 promotes pancreatic adenocarcinoma cell proliferation and migration by positively regulating SMAD6. World J Gastrointest Oncol 2022; 14(11): 2157-2169 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i11/2157.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i11.2157 |
