Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	78804
Country	China

Received	2022-07-15 09:41
Peer-Review Started	2022-07-15 09:44
To Make the First Decision
Return for Revision	2022-08-08 02:01
Revised	2022-09-05 05:38
Second Decision	2022-10-12 03:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-10-12 17:11
Articles in Press	2022-10-12 17:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-11-04 06:59
Publish the Manuscript Online	2022-11-15 10:19

ISSN	1948-5204 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Jing Gu, Ya-Jun Li, Fang Wang and Ting Ye
ORCID	Author(s) ORCID Number Ya-Jun Li http://orcid.org/0000-0002-2728-3237 Ting Ye http://orcid.org/0000-0003-3497-0737
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81860442 Ningxia Natural Science Foundation Project 2022AAC03525
Corresponding Author	Ya-Jun Li, Doctor, DPhil, Chief Doctor, Department of Gastroenterology, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan 750004, Ningxia Hui Autonomous Region, China. lyajundoc@126.com
Key Words	Gastric cancer; MiR-30e-3p; THO complex2; PI3K/AKT/mTOR signaling
Core Tip	Gastric cancer (GC) is a common digestive cancer with high morbidity and mortality rates worldwide. Considerable effort has been expended in understanding the mechanism of GC development and metastasis. Given that microRNAs have been found to participate in the regulation of GC progression, we explored the expression and function of miR-30e-3p in GC development and revealed that knockdown of THO complex 2 (THOC2) inhibited the growth and metastatic behaviors of GC cells. After investigating signaling pathways involved in miR-30e-3p regulation were investigated, we found that the miR-30e-3p/THOC2 axis regulated the PI3K/AKT/mTOR pathway in GC.
Publish Date	2022-11-15 10:19
Citation	Gu XJ, Li YJ, Wang F, Ye T. MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling. World J Gastrointest Oncol 2022; 14(11): 2170-2182
URL	https://www.wjgnet.com/1948-5204/full/v14/i11/2170.htm
DOI	https://dx.doi.org/10.4251/wjgo.v14.i11.2170

Full Article (PDF)	WJGO-14-2170.pdf
Full Article (Word)	WJGO-14-2170.docx
Manuscript File	78804_Auto_Edited-LM.docx
Answering Reviewers	78804-Answering reviewers.pdf
Audio Core Tip	78804-Audio core tip.m4a
Biostatistics Review Certificate	78804-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	78804-Conflict-of-interest statement.pdf
Copyright License Agreement	78804-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	78804-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	78804-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	78804-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	78804-Language certificate.pdf
Supplementary Material	78804-Supplementary material.pdf
Peer-review Report	78804-Peer-review(s).pdf
Scientific Editor Work List	78804-Scientific editor work list.pdf
CrossCheck Report	78804-CrossCheck report.pdf