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Articles Published Processes
11/23/2022 9:44:44 AM | Browse: 234 | Download: 647
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Received |
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2022-07-15 10:50 |
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Peer-Review Started |
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2022-07-15 10:51 |
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To Make the First Decision |
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Return for Revision |
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2022-08-21 11:09 |
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Revised |
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2022-09-04 13:30 |
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Second Decision |
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2022-10-11 03:12 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-10-12 00:39 |
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Articles in Press |
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2022-10-12 00:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-10-09 08:50 |
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Typeset the Manuscript |
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2022-11-07 06:00 |
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Publish the Manuscript Online |
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2022-11-23 09:44 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Molecular mechanisms of Baihedihuang decoction as a treatment for breast cancer related anxiety: A network pharmacology and molecular docking study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhong-Hui Li, Guo-Hua Yang and Fang Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Fang Wang, MD, Chief Doctor, Department of Oncology, Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6 Huajiadi Street, Chaoyang District, Beijing 100102, China. wf074500@163.com |
| Key Words |
Network pharmacology; Molecular docking; Baihedihuang decoction; Breast cancer related anxiety; Mechanism of action |
| Core Tip |
Baihedihuang decoction (BD) has significant effects on breast cancer related anxiety; however, its molecular targets in this condition remain unknown. We conducted a network pharmacology and molecular docking study to determine whether BD ingredients target molecules and signaling pathways related to breast cancer related anxiety pathogenesis. The main active ingredients identified include verbascoside, β-sitosterol, stigmasterol, and catalpol. Target genes included CDK2, TP53, HTR2A, and ESR1, which are involved in cell cycle, apoptosis, cell autophagy, blood circulation, and other biological processes. Our results confirm that BD can treat breast cancer related anxiety through multi-component, multi-target, and multi-channel synergy. |
| Publish Date |
2022-11-23 09:44 |
| Citation |
Li ZH, Yang GH, Wang F. Molecular mechanisms of Baihedihuang decoction as a treatment for breast cancer related anxiety: A network pharmacology and molecular docking study. World J Clin Cases 2022; 10(33): 12104-12115 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i33/12104.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i33.12104 |
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