Publication Name	World Journal of Stem Cells
Manuscript ID	7889
Country	United States

Received	2013-12-08 12:41
Peer-Review Started	2013-12-08 13:39
To Make the First Decision	2014-01-16 08:15
Return for Revision	2014-01-17 12:07
Revised
Second Decision	2014-02-19 11:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-19 11:36
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-18 17:56
Publish the Manuscript Online	2014-04-28 14:14

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Familial Alzheimer’s disease modelling using induced pluripotent stem cell technology
Manuscript Source	Invited Manuscript
All Author List	Lisa Mohamet, Natalie J Miazga and Christopher M Ward
Funding Agency and Grant Number	Funding Agency Grant Number United Kingdom Biotechnology and Biosciences Research Council Engineering and Physical Sciences Research Council and the Technology Strategy Board
Corresponding Author	Dr. Christopher M Ward, Stem Cell Biology Group, Core Technology Facility, Faculty of Human and Medical Sciences, The University of Manchester, Manchester, 46 Grafton Street, Manchester M13 9NT, United Kingdom. christopher.ward@manchester.ac.uk
Key Words	Human induced pluripotent stem cells; Alzheimer’s disease; Neurodegenerative diseases; High-throughput screening assays; Cholinergic neurons; Drug discovery; Stratified medicine
Core Tip	Alzheimer’s disease (AD) affects 36 million people worldwide and is set to double by 2030. Progress in understanding AD has been hindered by a lack of suitable in vitro and in vivo models reflected in > 90% drug attrition rates. Induced pluripotent stem cells are an alternative source of neural cells that can be derived from patients’ somatic cells and exhibit AD pathophysiological phenotypes. These cells are amenable to HTS formats required for drug discovery applications. Harnessing this combined potential would provide an unprecedented opportunity to significantly reduce timeframes and costs associated with developing novel therapeutics, ultimately improving patient outcomes.
Publish Date	2014-04-28 14:14
Citation	Mohamet L, Miazga NJ, Ward CM. Familial Alzheimer’s disease modelling using induced pluripotent stem cell technology. World J Stem Cells 2014; 6(2): 239-247
URL	http://www.wjgnet.com/1948-0210/full/v6/i2/239.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i2.239

Full Article (PDF)	WJSC-6-239.pdf
Full Article (Word)	WJSC-6-239.doc
Manuscript File	7889-Review.docx
Answering Reviewers	7889-Answering reviewers.pdf
Copyright License Agreement	7889-Copyright assignment.pdf
Peer-review Report	7889-Peer review(s).pdf
Scientific Editor Work List	7889-Scientific editor work list.doc