Publication Name	World Journal of Gastroenterology
Manuscript ID	78969
Country	China

Received	2022-08-03 01:36
Peer-Review Started	2022-08-03 01:38
To Make the First Decision
Return for Revision	2022-11-17 05:36
Revised	2022-12-01 12:39
Second Decision	2023-01-04 04:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-01-04 18:05
Articles in Press	2023-01-04 18:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-01-06 07:24
Publish the Manuscript Online	2023-01-20 13:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Pulmonary cryptococcosis after immunomodulator treatment in patients with Crohn’s disease: Three case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Fei Fang, Xiang-Han Cao, Ling-Ya Yao and Qian Cao
ORCID	Author(s) ORCID Number Yan-Fei Fang http://orcid.org/0000-0001-9292-7206 Qian Cao http://orcid.org/0000-0001-7938-7532
Funding Agency and Grant Number
Corresponding Author	Qian Cao, PhD, Chief Doctor, Chief Physician, Inflammatory Bowel Disease Center, Sir Run Run Shaw Hospital, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. caoq@zju.edu.cn
Key Words	Crohn’s disease; Immunomodulator; Infliximab; Opportunistic infections; Pulmonary cryptococcosis; Case report
Core Tip	Corticosteroids and anti-tumor necrosis factor α mAbs are commonly used to treat Crohn's disease (CD). However, they may also contribute to an increased risk of opportunistic infections. In this article, we report three cases of pulmonary cryptococcosis in patients with CD after receiving immunomodulatory treatment. Pathogen identification mainly depends on pathological examination findings, but metagenomics can serve as an alternative tool. Patients with timely diagnosis generally have a good prognosis, but clinical alerts should be raised in those who are elderly and have comorbidities and dissemination phenotype.
Publish Date	2023-01-20 13:48
Citation	Fang YF, Cao XH, Yao LY, Cao Q. Pulmonary cryptococcosis after immunomodulator treatment in patients with Crohn’s disease: Three case reports. World J Gastroenterol 2023; 29(4): 758-765
URL	https://www.wjgnet.com/1007-9327/full/v29/i4/758.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i4.758

Full Article (PDF)	WJG-29-758.pdf
Full Article (Word)	WJG-29-758.docx
Manuscript File	78969_Auto_Edited-LM.docx
Answering Reviewers	78969-Answering reviewers.pdf
Audio Core Tip	78969-Audio core tip.mp3
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Scientific Editor Work List	78969-Scientific editor work list.pdf
CrossCheck Report	78969-CrossCheck report.pdf