Publication Name	World Journal of Clinical Oncology
Manuscript ID	79109
Country	Japan

Received	2022-08-03 18:37
Peer-Review Started	2022-08-03 18:40
To Make the First Decision
Return for Revision	2022-08-30 14:41
Revised	2022-09-12 07:34
Second Decision	2022-10-18 03:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-10-18 17:08
Articles in Press	2022-10-18 17:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-11-08 03:26
Publish the Manuscript Online	2022-11-21 04:25

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors
Manuscript Source	Unsolicited Manuscript
All Author List	Winn Aung, Atsushi B Tsuji, Kenjiro Hanaoka and Tatsuya Higashi
ORCID	Author(s) ORCID Number Winn Aung http://orcid.org/0000-0002-0896-7158 Atsushi B Tsuji http://orcid.org/0000-0003-2726-288X Kenjiro Hanaoka http://orcid.org/0000-0003-0797-4038 Tatsuya Higashi http://orcid.org/0000-0002-8338-4737
Funding Agency and Grant Number	Funding Agency Grant Number Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science 21K07740
Corresponding Author	Winn Aung, MBBS, PhD, Senior Researcher, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. winn.aung@qst.go.jp
Key Words	Photodynamic therapy; Near-infrared; Photosensitizer; Folate receptor; Fluorescence; Cancer
Core Tip	Photodynamic therapy (PDT) is a minimally invasive cancer therapy and photosensitizers (PS) with optimal properties are crucial for enhancing the efficacy of PDT. We evaluated the therapeutic efficacy of a folate receptor (FR)-targeted, near-infrared (NIR)-sensitive PS (FolateSiR-1). FolateSiR-1 showed FR specificity in vitro and in vivo and functions as a tumor-damaging PS by inducing necrosis, apoptosis, and cell growth inhibition upon activation with NIR light. Our findings suggest that FolateSiR-1 is effective in FR-targeted NIR-PDT with low side effects and has potential for presenting new and effective treatment options for FR-overexpressing tumors.
Publish Date	2022-11-21 04:25
Citation	Aung W, Tsuji AB, Hanaoka K, Higashi T. Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors. World J Clin Oncol 2022; 13(11): 880-895
URL	https://www.wjgnet.com/2218-4333/full/v13/i11/880.htm
DOI	https://dx.doi.org/10.5306/wjco.v13.i11.880

Full Article (PDF)	WJCO-13-880.pdf
Full Article (Word)	WJCO-13-880.docx
The ARRIVE Guidelines	79109-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	79109_Auto_Edited-LM.docx
Answering Reviewers	79109-Answering reviewers.pdf
Audio Core Tip	79109-Audio core tip.m4a
Biostatistics Review Certificate	79109-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	79109-Conflict-of-interest statement.pdf
Copyright License Agreement	79109-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	79109-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	79109-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	79109-Language certificate.pdf
Peer-review Report	79109-Peer-review(s).pdf
Scientific Misconduct Check	79109-CrossCheck.png
Scientific Misconduct Check	79109-Bing-Gong ZM-2.png
Scientific Editor Work List	79109-Scientific editor work list.pdf
CrossCheck Report	79109-CrossCheck report.pdf