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Articles Published Processes
11/21/2022 4:25:35 AM | Browse: 606 | Download: 1936
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Received |
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2022-08-03 18:37 |
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Peer-Review Started |
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2022-08-03 18:40 |
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First Decision by Editorial Office Director |
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2022-08-29 07:52 |
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Return for Revision |
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2022-08-30 14:41 |
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Revised |
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2022-09-12 07:34 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-10-18 03:28 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-10-18 17:08 |
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Articles in Press |
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2022-10-18 17:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-11-08 03:26 |
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Publish the Manuscript Online |
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2022-11-21 04:25 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Winn Aung, Atsushi B Tsuji, Kenjiro Hanaoka and Tatsuya Higashi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science |
21K07740 |
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| Corresponding Author |
Winn Aung, MBBS, PhD, Senior Researcher, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. winn.aung@qst.go.jp |
| Key Words |
Photodynamic therapy; Near-infrared; Photosensitizer; Folate receptor; Fluorescence; Cancer |
| Core Tip |
Photodynamic therapy (PDT) is a minimally invasive cancer therapy and photosensitizers (PS) with optimal properties are crucial for enhancing the efficacy of PDT. We evaluated the therapeutic efficacy of a folate receptor (FR)-targeted, near-infrared (NIR)-sensitive PS (FolateSiR-1). FolateSiR-1 showed FR specificity in vitro and in vivo and functions as a tumor-damaging PS by inducing necrosis, apoptosis, and cell growth inhibition upon activation with NIR light. Our findings suggest that FolateSiR-1 is effective in FR-targeted NIR-PDT with low side effects and has potential for presenting new and effective treatment options for FR-overexpressing tumors. |
| Publish Date |
2022-11-21 04:25 |
| Citation |
Aung W, Tsuji AB, Hanaoka K, Higashi T. Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors. World J Clin Oncol 2022; 13(11): 880-895 |
| URL |
https://www.wjgnet.com/2218-4333/full/v13/i11/880.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v13.i11.880 |
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