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Articles Published Processes
12/21/2022 3:07:33 AM | Browse: 519 | Download: 1387
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Received |
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2022-08-04 07:01 |
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Peer-Review Started |
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2022-08-04 07:05 |
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First Decision by Editorial Office Director |
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2022-09-29 23:06 |
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Return for Revision |
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2022-09-29 23:06 |
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Revised |
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2022-10-07 08:36 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-11-17 04:28 |
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Second Decision by Editor-in-Chief |
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2022-11-18 01:51 |
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Final Decision by Editorial Office Director |
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2022-11-30 18:06 |
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Articles in Press |
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2022-11-30 18:06 |
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Edit the Manuscript by Language Editor |
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2022-11-12 01:41 |
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Typeset the Manuscript |
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2022-12-13 13:49 |
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Publish the Manuscript Online |
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2022-12-21 03:07 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Reproductive Biology |
| Manuscript Type |
Basic Study |
| Article Title |
SPOC domain-containing protein 1 regulates the proliferation and apoptosis of human spermatogonial stem cells through adenylate kinase 4
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dai Zhou, Fang Zhu, Zeng-Hui Huang, Huan Zhang, Li-Qing Fan and Jing-Yu Fan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Changsha |
kq2202491 |
| Research Grant of CITIC-Xiangya |
YNXM 202109 and YNXM 202115 |
| National Natural Science Foundation for Young Scholars of China |
No. 82201771 |
| National Natural Science Foundation of China |
No. 32270912 |
| Hunan Provincial Grant for Innovative Province Construction |
No. 2019SK4012 |
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| Corresponding Author |
Jing-Yu Fan, MD, PhD, Researcher, Department of Chemistry and Biochemistry, University of South Carolina, Chen Biochem 631 Sumter ST Garc 109, Columbia , SC 29208, United States. jingyu@email.sc.edu |
| Key Words |
Human; Testis; Spermatogonial stem cells; SPOC domain-containing protein 1; Adenylate kinase 4; Proliferation |
| Core Tip |
In this study, we reported the dominant expression of SPOC domain-containing protein 1 (SPOCD1) in human spermatogonial stem cells (SSCs). Knockdown of SPOCD1 in SSC caused a significant decrease in proliferation and self-renewal, and the induction of apoptosis. RNA sequencing showed that SPOCD1 deficiency caused significant downregulation of genes such as adenylate kinase 4 (AK4), and overexpression of AK4 in SPOCD1-deficient cells reversed the phenotypic alterations induced by SPOCD knockdown. Additionally, we found significant downregulation of SPOCD1 in non-obstructive azoospermia patients. These results broaden our understanding of human SSC fate determination and also provide a target for treating male infertility. |
| Publish Date |
2022-12-21 03:07 |
| Citation |
Zhou D, Zhu F, Huang ZH, Zhang H, Fan LQ, Fan JY. SPOC domain-containing protein 1 regulates the proliferation and apoptosis of human spermatogonial stem cells through adenylate kinase 4. World J Stem Cells 2022; 14(12): 822-838 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i12/822.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i12.822 |
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