Publication Name	World Journal of Clinical Oncology
Manuscript ID	79141
Country	Brazil

Received	2022-08-06 01:39
Peer-Review Started	2022-08-06 01:42
To Make the First Decision
Return for Revision	2022-09-05 09:42
Revised	2022-09-20 02:59
Second Decision	2022-10-11 03:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-10-11 18:33
Articles in Press	2022-10-11 18:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-10-25 17:02
Typeset the Manuscript	2022-11-16 06:37
Publish the Manuscript Online	2022-11-21 04:25

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Influence of Helicobacter pylori oncoprotein CagA in gastric cancer: A critical-reflective analysis
Manuscript Source	Invited Manuscript
All Author List	Fabrício Freire de Melo, Hanna Santos Marques, Samuel Luca Rocha Pinheiro, Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Kádima Nayara Teixeira, Cláudio Lima Souza and Márcio Vasconcelos Oliveira
ORCID	Author(s) ORCID Number Fabrício Freire de Melo http://orcid.org/0000-0002-5680-2753 Hanna Santos Marques http://orcid.org/0000-0001-5741-1570 Samuel Luca Rocha Pinheiro http://orcid.org/0000-0002-8877-892X Fabian Fellipe Bueno Lemos http://orcid.org/0000-0002-4686-7086 Marcel Silva Luz http://orcid.org/0000-0003-1650-5807 Cláudio Lima Souza http://orcid.org/0000-0002-8094-8357 Márcio Vasconcelos Oliveira http://orcid.org/0000-0002-8959-0478
Funding Agency and Grant Number	Funding Agency Grant Number National Council for Scientific and Technological Development, CNPq Brazil
Corresponding Author	Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Estrada do Bem Querer, 3293-3391 - Candeias, Vitória da Conquista 45029-094, Brazil. freiremeloufba@gmail.com
Key Words	Helicobacter pylori; Virulence factors; CagA; Gastric cancer; EPIYA motifs; Hit-and-run carcinogenesis
Core Tip	CagA is a translocated effector protein that induces morphofunctional modifications in gastric epithelial cells and persistent chronic gastric inflammation. Upon translocation, the bacterial oncoprotein acts as a promiscuous scaffold or hub protein, which is capable of disrupting multiple host signaling pathways, thereby inducing precancerous cellular alterations. This article aims at performing a general approach on Helicobacter pylori- and CagA-related oncogenic mechanisms as well as to discuss the novelties and perspectives in this field.
Publish Date	2022-11-21 04:25
Citation	Freire de Melo F, Marques HS, Rocha Pinheiro SL, Lemos FFB, Silva Luz M, Nayara Teixeira K, Souza CL, Oliveira MV. Influence of Helicobacter pylori oncoprotein CagA in gastric cancer: A critical-reflective analysis. World J Clin Oncol 2022; 13(11): 866-879
URL	https://www.wjgnet.com/2218-4333/full/v13/i11/866.htm
DOI	https://dx.doi.org/10.5306/wjco.v13.i11.866

Full Article (PDF)	WJCO-13-866.pdf
Full Article (Word)	WJCO-13-866.docx
Manuscript File	79141_Auto_Edited-LM_Kerr C_Clear Copy.docx
Answering Reviewers	79141-Answering reviewers.pdf
Audio Core Tip	79141-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	79141-Conflict-of-interest statement.pdf
Copyright License Agreement	79141-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	79141-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	79141-Language certificate.pdf
Peer-review Report	79141-Peer-review(s).pdf
Scientific Misconduct Check	79141-Bing-Gao CC-2.png
Scientific Editor Work List	79141-Scientific editor work list.pdf
CrossCheck Report	79141-CrossCheck report.pdf