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Articles Published Processes
11/23/2022 9:44:44 AM | Browse: 253 | Download: 736
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Received |
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2022-08-07 12:36 |
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Peer-Review Started |
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2022-08-07 12:38 |
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To Make the First Decision |
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Return for Revision |
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2022-09-25 10:34 |
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Revised |
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2022-10-04 08:52 |
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Second Decision |
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2022-10-24 03:20 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-10-24 08:49 |
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Articles in Press |
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2022-10-24 08:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-10-31 01:07 |
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Publish the Manuscript Online |
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2022-11-23 09:44 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Coexistence of anaplastic lymphoma kinase rearrangement in lung adenocarcinoma harbouring epidermal growth factor receptor mutation: A single-center study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei-Xiang Zhong and Xi-Feng Wei |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wei-Xiang Zhong, MA, Attending Doctor, Surgeon, Department of Thoracic Surgery, First Affiliated Hospital of Gannan Medical University, No 128 Jinling West Road, Ganzhou 341000, Jiangxi Province, China. bronco067@126.com |
| Key Words |
Lung adenocarcinoma; Epidermal growth factor receptor mutation; Anaplastic lymphoma kinase rearrangement; Co-mutation; Tyrosine kinase inhibitor |
| Core Tip |
This study retrospectively analyzed the clinicopathological features of patients with co-mutations of EGFR and ALK genes in lung adenocarcinoma, and collected follow-up data of these patients, especially focusing on the tyrosine kinase inhibitors (TKIs) selected and its therapeutic effect in the real world from a single institute experience. The results showed that the positive rate of lung adenocarcinoma patients with co-mutations of EGFR and ALK genes, which were more common in women, non-smoking and stage IV patients with bone metastasis, was relatively high in Gannan region, which may be related to regional heterogeneity. EGFR-TKIs were their preferred drugs for targeted therapy in these patients, but the therapeutic effect is not good. EGFR/ALK dual-TKIs may be more effective targeted drugs. |
| Publish Date |
2022-11-23 09:44 |
| Citation |
Zhong WX, Wei XF. Coexistence of anaplastic lymphoma kinase rearrangement in lung adenocarcinoma harbouring epidermal growth factor receptor mutation: A single-center study. World J Clin Cases 2022; 10(33): 12164-12174 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i33/12164.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i33.12164 |
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