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Articles Published Processes
1/6/2023 2:52:58 AM | Browse: 299 | Download: 723
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Received |
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2022-08-13 23:23 |
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Peer-Review Started |
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2022-08-10 02:28 |
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To Make the First Decision |
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Return for Revision |
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2022-10-20 20:28 |
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Revised |
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2022-10-25 03:39 |
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Second Decision |
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2022-11-18 04:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-11-19 00:50 |
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Articles in Press |
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2022-11-19 00:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-12-15 00:55 |
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Typeset the Manuscript |
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2022-12-30 04:16 |
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Publish the Manuscript Online |
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2023-01-06 02:52 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Current opinion in the regulation of small intestinal magnesium absorption
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Siriporn Chamniansawat, Nasisorn Suksridechacin and Narongrit Thongon |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Narongrit Thongon, PhD, Associate Professor, Division of Physiology, Department of Medical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Road, Saensook, Muang 20131, Chonburi, Thailand. narongritt@buu.ac.th |
| Key Words |
Hormone; Mg2+ absorption; Paneth cells; Proton pump inhibitor; Regulation; Small intestine |
| Core Tip |
Small-intestinal epithelium absorbs digested Mg2+ through both transcellular active and paracellular passive mechanisms. Several regulatory factors of small-intestinal Mg2+ uptake have been reported. Parathyroid hormone and fibroblast growth factor-23 directly inhibit transcellular Mg2+ absorption in the duodenum, jejunum, and ileum. The apical proton triggered acid-sensing ion-channel 1a and purinergic P2Y2 receptor activities, which stimulated mucosal bicarbonate secretion (MBS). Secreted bicarbonate induced MgCO3 precipitation that suppressed small-intestinal Mg2+ absorption. Omeprazole suppressed Mg2+ absorption in the duodenum, jejunum, and ileum via higher MBS, lower mucosal transient receptor potential melastatin 6 homodimer channel and transient receptor potential melastatin 6/7 homodimer channel activity, Paneth cell dysfunction, and higher intestinal inflammation and villous atrophy. |
| Publish Date |
2023-01-06 02:52 |
| Citation |
Chamniansawat S, Suksridechacin N, Thongon N. Current opinion in the regulation of small intestinal magnesium absorption. World J Gastroenterol 2023; 29(2): 332-342 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i2/332.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i2.332 |
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