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Articles Published Processes
12/27/2022 9:49:43 AM | Browse: 174 | Download: 734
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Received |
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2022-08-25 07:47 |
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Peer-Review Started |
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2022-08-25 07:50 |
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To Make the First Decision |
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Return for Revision |
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2022-09-03 01:25 |
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Revised |
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2022-09-11 22:44 |
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Second Decision |
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2022-11-07 03:26 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-11-07 21:41 |
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Articles in Press |
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2022-11-07 21:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-11-09 07:42 |
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Publish the Manuscript Online |
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2022-12-27 09:49 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ryo Yamamoto, Sayuri Suzuki, Koichiro Homma, Shintaro Yamaguchi, Tomohisa Sujino and Junichi Sasaki |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Koichiro Homma, MD, PhD, Assistant Professor, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 1608582, Japan. homma@keio.jp |
| Key Words |
Hydrogen molecule; Intestinal ischemia; Ischemia-reperfusion injury; Tissue protection; Non-operative management; Leucine-rich repeat-containing G-protein-coupled 5 |
| Core Tip |
Distal ileum of rats was observed after 60-min mesenteric artery occlusion (ischemia), 60-min reperfusion following 60-min occlusion (reperfusion), or ischemia-reperfusion with the same duration under continuous 3% hydrogen gas inhalation (hydrogen). Immunofluorescence staining with caspase-3 and leucine-rich repeat-containing G-protein-coupled 5 (LGR5) (a specific marker of intestinal stem cell) identified ischemia damaged the epithelial layer at the tip of the villi, whereas reperfusion induced extensive apoptosis of intestinal stem cells that was mitigated by hydrogen. In addition, quantitative polymerase chain reaction revealed the LGR5 expression of the tissues was higher in rats with hydrogen inhalation than in those with reperfusion injury. |
| Publish Date |
2022-12-27 09:49 |
| Citation |
Yamamoto R, Suzuki S, Homma K, Yamaguchi S, Sujino T, Sasaki J. Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion. World J Gastrointest Surg 2022; 14(12): 1329-1339 |
| URL |
https://www.wjgnet.com/1948-9366/full/v14/i12/1329.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v14.i12.1329 |
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