Publication Name	World Journal of Diabetes
Manuscript ID	79323
Country	China

Received	2022-08-16 01:37
Peer-Review Started	2022-08-16 01:41
To Make the First Decision
Return for Revision	2022-09-04 06:41
Revised	2022-09-15 17:29
Second Decision	2022-10-10 03:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-10-11 17:27
Articles in Press	2022-10-11 17:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-10-06 23:33
Typeset the Manuscript	2022-11-07 03:53
Publish the Manuscript Online	2022-11-11 10:05

ISSN	1948-9358 (online)
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Dietary Nε-(carboxymethyl) lysine affects cardiac glucose metabolism and myocardial remodeling in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Zhong-Qun Wang and Zhen Sun
ORCID	Author(s) ORCID Number Zhong-Qun Wang http://orcid.org/0000-0003-3590-9313 Zhen Sun http://orcid.org/0000-0003-3368-1976
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82070455 Natural Science Foundation of Jiangsu Province BK20201225 Medical Innovation Team Project of Jiangsu Province CXTDA2017010 Research and Innovation Funding Project for College Students in Experimental Animal Center of Jiangsu University
Corresponding Author	Zhen Sun, PhD, Doctor, Doctor, Department of Cardiology, Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Zhenjiang 212001, Jiangsu Province, China. 1398041019@qq.com
Key Words	Diet; Myocardial remodeling; Glucose metabolism; Nε-(carboxymethyl)lysine; C57 BL/6 mice
Core Tip	Nε-(carboxymethyl)lysine (CML) exists in daily diet and is harmful to health. We established in vitro and in vivo models to investigate the effects of dietary CML (dCML) on the heart. We found that long-term dCML induced insulin resistance and elevated serum CML level. 18F-fluorodeoxyglucose imaging indicated that dCML promoted myocardial glucose uptake, but the glucose metabolism was disrupted. Myocardial fibrosis, apoptosis, and hypertrophy were significantly enhanced by dCML. In the cell model, CML supplementation promoted cardiomyocyte apoptosis, cellular hypertrophy, and collagen I expression, and also inhibited pathways involved in glucose metabolism.
Publish Date	2022-11-11 10:05
Citation	Wang ZQ, Sun Z. Dietary Nε-(carboxymethyl)lysine affects cardiac glucose metabolism and myocardial remodeling in mice. World J Diabetes 2022; 13(11): 972-985
URL	https://www.wjgnet.com/1948-9358/full/v13/i11/972.htm
DOI	https://dx.doi.org/10.4239/wjd.v13.i11.972

Full Article (PDF)	WJD-13-972.pdf
Full Article (Word)	WJD-13-972.docx
The ARRIVE Guidelines	79323-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	79323_Auto_Edited-LM.docx
Answering Reviewers	79323-Answering reviewers.pdf
Audio Core Tip	79323-Audio core tip.mp3
Biostatistics Review Certificate	79323-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	79323-Conflict-of-interest statement.pdf
Copyright License Agreement	79323-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	79323-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	79323-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	79323-Language certificate.pdf
Peer-review Report	79323-Peer-review(s).pdf
Scientific Misconduct Check	79323-Bing-Chen YL-2.png
Scientific Editor Work List	79323-Scientific editor work list.pdf
CrossCheck Report	79323-CrossCheck report.pdf