BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
3/15/2023 3:41:16 PM | Browse: 358 | Download: 1094
 |
Received |
|
2022-08-17 05:17 |
|
Peer-Review Started |
|
2022-08-17 05:20 |
|
First Decision by Editorial Office Director |
|
2022-12-12 21:14 |
|
Return for Revision |
|
2022-12-12 21:14 |
|
Revised |
|
2023-01-05 01:58 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2023-02-15 03:52 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2023-02-15 21:01 |
|
Articles in Press |
|
2023-02-15 21:01 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2023-03-09 12:44 |
|
Publish the Manuscript Online |
|
2023-03-15 15:41 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
miR-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-induced β-cells by targeting EZH2
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Kai Duan, Yong-Xiang Sun, Hong-Yun Wang, Yan-Yan Xu, Shi-Zhen Fan, Jin-Ya Tian, Yong Yu, Yan-Yun Zhao and Yan-Li Jiang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical Science and Technology Key Project of Henan Province |
No.2018020733 |
|
| Corresponding Author |
Xiao-Kai Duan, Doctor, MMed, Chief Physician, Department of General Practice, Zhengzhou First People’s Hospital, No. 56 Dongdajie Street, Zhengzhou 450052, Henan Province, China. medicalworkers@126.com |
| Key Words |
miR-124; Enhancer of zeste homolog 2; Diabetes; Insulin secretion; Proliferation; Apoptosis |
| Core Tip |
In clinical studies, miR-124 is highly expressed in the serum of patients with diabetes and in pancreatic islet β-cells. In this study, the role and mechanism of miR-124 in diabetes was explored. miR-124 was highly expressed in the diabetic mice, suggesting that the miR-124 was involved in the pathological process of diabetes. In high glucose-induced Min6 cells, miR-124 regulated the insulin secretion, proliferation and apoptosis of islet β-cells by targeting enhancer of zeste homolog 2 (EZH2), indicating that miR-124 was involved in the pathological process of diabetes by targeting EZH2, which might provide a new idea and target for the diagnosis and treatment of diabetes. |
| Publish Date |
2023-03-15 15:41 |
| Citation |
Duan XK, Sun YX, Wang HY, Xu YY, Fan SZ, Tian JY, Yu Y, Zhao YY, Jiang YL. miR-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-induced β-cells by targeting EZH2. World J Diabetes 2024; In press
|
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i3/209.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i3.209 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
