Publication Name	World Journal of Gastroenterology
Manuscript ID	79458
Country	China

Received	2022-08-27 07:18
Peer-Review Started	2022-08-27 07:22
To Make the First Decision
Return for Revision	2022-09-25 06:00
Revised	2022-09-30 10:57
Second Decision	2022-10-20 03:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-10-20 17:00
Articles in Press	2022-10-20 17:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-10-31 01:07
Publish the Manuscript Online	2022-11-04 05:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions
Manuscript Source	Invited Manuscript
All Author List	Yuan-Bin Liu and Ming-Kai Chen
ORCID	Author(s) ORCID Number Yuan-Bin Liu http://orcid.org/0000-0002-8640-0288 Ming-Kai Chen http://orcid.org/0000-0003-2652-6863
Funding Agency and Grant Number
Corresponding Author	Ming-Kai Chen, MD, Chief Physician, Professor, Department of Gastroenterology, Renmin Hospital of Wuhan University, No. 99 Zhang Zhidong Road, Wuhan 430000, Hubei Province, China. kaimingchen@163.com
Key Words	Causes; Cirrhosis; Complications; Cost; Epidemiology; Burden; Feature
Core Tip	The global burden of liver cirrhosis continues to rise. In 2017, there were 520000 new cases of cirrhosis and chronic liver disease. In 2019, cirrhosis caused 1.48 million deaths, an increase of 8.1% compared to 2017, and its disability-adjusted life-years ranked 16th among all diseases. The global burden of cirrhosis due to hepatitis B virus and hepatitis C virus infection is decreasing, while the burden of cirrhosis due to alcohol and nonalcoholic fatty liver disease is increasing rapidly. We also outlined the recent epidemiology of the major complications and hepatocellular carcinoma in cirrhosis.
Publish Date	2022-11-04 05:24
Citation	Liu YB, Chen MK. Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions. World J Gastroenterol 2022; 28(41): 5910-5930
URL	https://www.wjgnet.com/1007-9327/full/v28/i41/5910.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i41.5910

Full Article (PDF)	WJG-28-5910.pdf
Full Article (Word)	WJG-28-5910.docx
Manuscript File	79458_Auto_Edited-LM.docx
Answering Reviewers	79458-Answering reviewers.pdf
Audio Core Tip	79458-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	79458-Conflict-of-interest statement.pdf
Copyright License Agreement	79458-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	79458-Language certificate.pdf
Peer-review Report	79458-Peer-review(s).pdf
Scientific Misconduct Check	79458-Bing-Chen YL-2.png
Scientific Editor Work List	79458-Scientific editor work list.pdf
CrossCheck Report	79458-CrossCheck report.pdf