Publication Name	World Journal of Orthopedics
Manuscript ID	79472
Country	Indonesia

Received	2022-09-01 03:47
Peer-Review Started	2022-09-01 03:52
To Make the First Decision
Return for Revision	2022-12-19 10:57
Revised	2022-12-22 07:42
Second Decision	2023-02-02 03:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-02-02 12:57
Articles in Press	2023-02-02 12:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-02-08 08:37
Publish the Manuscript Online	2023-02-17 15:13

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Mechanism of spinal cord injury regeneration and the effect of human neural stem cells-secretome treatment in rat model
Manuscript Source	Unsolicited Manuscript
All Author List	I Nyoman Semita, Dwikora Novembri Utomo and Heri Suroto
ORCID	Author(s) ORCID Number I Nyoman Semita http://orcid.org/0000-0003-0363-0254 Dwikora Novembri Utomo http://orcid.org/0000-0002-7832-5695 Heri Suroto http://orcid.org/0000-0002-9384-897X
Funding Agency and Grant Number
Corresponding Author	Dwikora Novembri Utomo, MD, Surgeon, Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Airlangga, Manyar Tirtosari Street IV/7, Surabaya 60118, East Java, Indonesia. dwikora-novembri-u@fk.unair.ac.id
Key Words	Secretome; Regeneration mechanism; Spinal cord injury; Locomotor; Biomarkers
Core Tip	The human neural stem cell (HNSC)-secretomes is effective in spinal cord injury (SCI) treatment, based on locomotor function improvement, decreased size of spinal cord lesions, and biomarkers expression. Based on partial least squares structural equation modeling analysis, the regeneration mechanism of SCI started with pro-inflammation, anti-inflammation, anti-apoptotic, neuroangiogenesis, neurogenesis, finally, locomotor improvement.
Publish Date	2023-02-17 15:13
Citation	Semita IN, Utomo DN, Suroto H. Mechanism of spinal cord injury regeneration and the effect of human neural stem cells-secretome treatment in rat model. World J Orthop 2023; 14(2): 64-82
URL	https://www.wjgnet.com/2218-5836/full/v14/i2/64.htm
DOI	https://dx.doi.org/10.5312/wjo.v14.i2.64

Full Article (PDF)	WJO-14-64.pdf
Full Article (Word)	WJO-14-64.docx
Manuscript File	79472_Auto_Edited-LM.docx
Answering Reviewers	79472-Answering reviewers.pdf
Audio Core Tip	79472-Audio core tip.ogg
Biostatistics Review Certificate	79472-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	79472-Conflict-of-interest statement.pdf
Copyright License Agreement	79472-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	79472-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	79472-Language certificate.pdf
Peer-review Report	79472-Peer-review(s).pdf
Scientific Misconduct Check	79472-Bing-Wang JJ-2.png
Scientific Editor Work List	79472-Scientific editor work list.pdf
CrossCheck Report	79472-CrossCheck report.pdf