Publication Name	World Journal of Virology
Manuscript ID	79581
Country	Türkiye

Received	2022-08-27 19:56
Peer-Review Started	2022-08-27 19:58
To Make the First Decision
Return for Revision	2022-09-27 11:53
Revised	2022-10-03 18:11
Second Decision	2022-11-21 03:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-11-22 03:05
Articles in Press	2022-11-22 03:05
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-11-17 08:03
Typeset the Manuscript	2023-01-12 03:26
Publish the Manuscript Online	2023-01-18 03:45

ISSN	2220-3249 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Severe acute respiratory syndrome coronavirus 2 may cause liver injury via Na+/H+ exchanger
Manuscript Source	Invited Manuscript
All Author List	Medine Cumhur Cure and Erkan Cure
ORCID	Author(s) ORCID Number Medine Cumhur Cure http://orcid.org/0000-0001-9253-6459 Erkan Cure http://orcid.org/0000-0001-7807-135X
Funding Agency and Grant Number
Corresponding Author	Medine Cumhur Cure, MD, Associate Professor, Department of Biochemistry, Private Tanfer Hospital, Mecidiyeköy, Aytekin Kotil Cd. No: 25, Şişli, Istanbul 34394, Türkiye. medinecure@yahoo.com
Key Words	Liver; Hepatocyte; Severe acute respiratory syndrome coronavirus 2; COVID-19; Na+/H+ exchanger; Sodium-proton pump
Core Tip	Severe acute respiratory syndrome coronavirus 2 readily infects the liver by angiotensin-converting enzyme 2. Increased angiotensin II causes Na+/H+ exchanger (NHE) overstimulation allowing the accumulation of Na+ and Ca2+ in hepatocytes. Thus, hepatocytes are damaged and eventually die. Increased cytokine release increases fibrinogen levels, enhancing thrombotic events. Cytokine storms can be triggered by NHE overstimulation. Severe acute respiratory syndrome coronavirus 2-induced NHE overstimulation can change bile acid structure, which disrupts gut microbiota and can trigger cytokine storms. Liver damage from the virus can be considered the most important cause of disease progression and mortality.
Publish Date	2023-01-18 03:45
Citation	Cumhur Cure M, Cure E. Severe acute respiratory syndrome coronavirus 2 may cause liver injury via Na+/H+ exchanger. World J Virol 2023; 12(1): 12-21
URL	https://www.wjgnet.com/2220-3249/full/v12/i1/12.htm
DOI	https://dx.doi.org/10.5501/wjv.v12.i1.12

Full Article (PDF)	WJV-12-12.pdf
Full Article (Word)	WJV-12-12.docx
Manuscript File	79581_Auto_Edited-LM.docx
Answering Reviewers	79581-Answering reviewers.pdf
Audio Core Tip	79581-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	79581-Conflict-of-interest statement.pdf
Copyright License Agreement	79581-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	79581-Language certificate.pdf
Peer-review Report	79581-Peer-review(s).pdf
Scientific Misconduct Check	79581-Bing-Chang KL-2.png
Scientific Editor Work List	79581-Scientific editor work list.pdf
CrossCheck Report	79581-CrossCheck report.pdf