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Articles Published Processes
11/25/2022 2:19:17 AM | Browse: 406 | Download: 1195
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Received |
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2022-09-02 06:06 |
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Peer-Review Started |
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2022-09-02 06:09 |
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To Make the First Decision |
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Return for Revision |
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2022-09-30 04:49 |
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Revised |
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2022-09-30 16:08 |
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Second Decision |
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2022-11-14 03:27 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-11-17 22:49 |
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Articles in Press |
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2022-11-17 22:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-11-10 18:45 |
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Typeset the Manuscript |
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2022-11-18 09:29 |
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Publish the Manuscript Online |
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2022-11-25 02:19 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Virological and histological evaluation of intestinal samples in COVID-19 patients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dajana Cuicchi, Liliana Gabrielli, Maria Lucia Tardio, Giada Rossini, Antonietta D’Errico, Pierluigi Viale, Tiziana Lazzarotto and Gilberto Poggioli |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dajana Cuicchi, MD, PhD, Surgeon, Department of Medical and Surgical Sciences, Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 9, Bologna 40138, Italy. dajana.cuicchi@aosp.bo.it |
| Key Words |
COVID-19; SARS-CoV-2; Intestinal infection; Intestinal samples; Intestinal tropism; Rectal samples |
| Core Tip |
The detection of viral RNA in gastrointestinal tissue samples has not been adequately investigated. In this trial, 53 rectal biopsies and 6 surgical specimens from coronavirus disease 2019 patients were analyzed, with the primary objective of detecting severe acute respiratory syndrome coronavirus-2 RNA, using real time reverse transcriptase-polymerase chain reaction, and evaluating the histological features. Viral RNA was not detectable in any of the rectal biopsies performed (0/53). Histological examination of rectal biopsies showed no enterocyte damage, but mild inflammatory infiltration. Viral RNA was detected in 2 surgical specimens of the 6 examined, both of which were from patients with active neoplastic disease. Histological examination also pointed out mild inflammatory infiltration and focal vasculitis. |
| Publish Date |
2022-11-25 02:19 |
| Citation |
Cuicchi D, Gabrielli L, Tardio ML, Rossini G, D’Errico A, Viale P, Lazzarotto T, Poggioli G. Virological and histological evaluation of intestinal samples in COVID-19 patients. World J Gastroenterol 2022; 28(44): 6282-6293 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i44/6282.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i44.6282 |
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