Publication Name	World Journal of Gastroenterology
Manuscript ID	79678
Country	Italy

Received	2022-09-02 06:06
Peer-Review Started	2022-09-02 06:09
First Decision by Editorial Office Director	2022-09-30 04:49
Return for Revision	2022-09-30 04:49
Revised	2022-09-30 16:08
Publication Fee Transferred
Second Decision by Editor	2022-11-14 03:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-11-17 22:49
Articles in Press	2022-11-17 22:49
Edit the Manuscript by Language Editor	2022-11-10 18:45
Typeset the Manuscript	2022-11-18 09:29
Publish the Manuscript Online	2022-11-25 02:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Virological and histological evaluation of intestinal samples in COVID-19 patients
Manuscript Source	Invited Manuscript
All Author List	Dajana Cuicchi, Liliana Gabrielli, Maria Lucia Tardio, Giada Rossini, Antonietta D’Errico, Pierluigi Viale, Tiziana Lazzarotto and Gilberto Poggioli
ORCID	Author(s) ORCID Number Dajana Cuicchi http://orcid.org/0000-0002-1504-4888 Pierluigi Viale http://orcid.org/0000-0003-1264-0008
Funding Agency and Grant Number
Corresponding Author	Dajana Cuicchi, MD, PhD, Surgeon, Department of Medical and Surgical Sciences, Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 9, Bologna 40138, Italy. dajana.cuicchi@aosp.bo.it
Key Words	COVID-19; SARS-CoV-2; Intestinal infection; Intestinal samples; Intestinal tropism; Rectal samples
Core Tip	The detection of viral RNA in gastrointestinal tissue samples has not been adequately investigated. In this trial, 53 rectal biopsies and 6 surgical specimens from coronavirus disease 2019 patients were analyzed, with the primary objective of detecting severe acute respiratory syndrome coronavirus-2 RNA, using real time reverse transcriptase-polymerase chain reaction, and evaluating the histological features. Viral RNA was not detectable in any of the rectal biopsies performed (0/53). Histological examination of rectal biopsies showed no enterocyte damage, but mild inflammatory infiltration. Viral RNA was detected in 2 surgical specimens of the 6 examined, both of which were from patients with active neoplastic disease. Histological examination also pointed out mild inflammatory infiltration and focal vasculitis.
Publish Date	2022-11-25 02:19
Citation	Cuicchi D, Gabrielli L, Tardio ML, Rossini G, D’Errico A, Viale P, Lazzarotto T, Poggioli G. Virological and histological evaluation of intestinal samples in COVID-19 patients. World J Gastroenterol 2022; 28(44): 6282-6293
URL	https://www.wjgnet.com/1007-9327/full/v28/i44/6282.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i44.6282

Full Article (PDF)	WJG-28-6282.pdf
Full Article (Word)	WJG-28-6282.docx
STROBE Statement	79678-STROBE-Statement-revision.pdf
Manuscript File	79678_Auto_Edited-LM.docx
Answering Reviewers	79678-Answering reviewers.pdf
Audio Core Tip	79678-Audio core tip.mp3
Biostatistics Review Certificate	79678-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	79678-Conflict-of-interest statement.pdf
Copyright License Agreement	79678-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	79678-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	79678-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	79678-Language certificate.pdf
Peer-review Report	79678-Peer-review(s).pdf
Scientific Misconduct Check	79678-Bing-Wang JJ-2.png
Scientific Editor Work List	79678-Scientific editor work list.pdf
CrossCheck Report	79678-CrossCheck report.pdf