Publication Name	World Journal of Gastroenterology
Manuscript ID	7971
Country	Canada

Received	2013-12-10 17:23
Peer-Review Started	2013-12-11 09:18
To Make the First Decision	2014-01-15 16:54
Return for Revision	2014-01-20 18:19
Revised	2014-01-21 01:25
Second Decision	2014-04-09 08:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-09 09:06
Articles in Press	2014-05-23 09:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-21 10:50
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Spontaneous free perforation of the small intestine in adults
Manuscript Source	Invited Manuscript
All Author List	Hugh James Freeman
Funding Agency and Grant Number
Corresponding Author	Hugh James Freeman, MD, CM, FRCPC, FACP, Professor, Department of Medicine, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada. hugfree@shaw.ca
Key Words	Free small bowel perforation; Crohn’s disease; Non-traumatic perforation; Celiac disease; Small bowel lymphoma; Vasculitis; Collagenous sprue; Biological agents; Monoclonal antibodies
Core Tip	Clinical presentation with “an acute abdomen” due to spontaneous “free” perforation usually requires urgent surgical intervention for survival. Often, the clinician is aware of an underlying disorder, but in others, this emergent situation may represent the initial clinical presentation of unrecognized Crohn’s disease or, even celiac disease already complicated by a superimposed lymphoma. Other rare causes include medical treatments for a variety of immune-mediated, inflammatory and neoplastic disorders, including some novel biological agents. Evidence also suggests that intestinal perforation could also reflect an occult genetically-based defect causing impaired connective tissue structure, synthesis and repair.
Publish Date	2014-08-07 10:34
Citation	Freeman HJ. Spontaneous free perforation of the small intestine in adults. World J Gastroenterol 2014; 20(29): 9990-9997
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/9990.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.9990

Full Article (PDF)	WJG-20-9990.pdf
Full Article (Word)	WJG-20-9990.doc
Manuscript File	7971-Review.doc
Answering Reviewers	7971-Answering reviewers.pdf
Copyright License Agreement	7971-Copyright assignment.pdf
Peer-review Report	7971-Peer review(s).pdf
Scientific Editor Work List	7971-Scientific editor work list.doc