Publication Name	World Journal of Clinical Cases
Manuscript ID	79720
Country	China

Received	2022-09-05 16:08
Peer-Review Started	2022-09-05 16:11
To Make the First Decision
Return for Revision	2022-10-27 00:39
Revised	2022-11-04 16:32
Second Decision	2022-11-18 03:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-11-18 08:32
Articles in Press	2022-11-18 08:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-11-28 05:47
Publish the Manuscript Online	2022-12-14 07:20

ISSN	2307-8960 (online)
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Category	Hematology
Manuscript Type	Case Report
Article Title	Genetic changes in refractory relapsed acute myeloid leukemia with NPM1 mutation: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Shuang-Ling Wang
ORCID	Author(s) ORCID Number Shuang-Ling Wang http://orcid.org/0000-0003-3405-611X
Funding Agency and Grant Number	Funding Agency Grant Number Shantou Science and Technology Planning Project of Guangdong Province SFK [2019] 79
Corresponding Author	Shuang-Ling Wang, MMed, Doctor, Doctor, Department of Hematology and Oncology, The Second Affiliated Hospital of Medical College of Shantou University, No. 69 Dongxia North Road, Shantou 515041, Guangdong Province, China. slwang_2006@126.com
Key Words	Acute myeloid leukemia; NPM1 mutation; Genetic variants; WT1; Case report
Core Tip	We report a patient with relapsed refractory acute myelomonocytic leukemia. Compared with the gene spectrum at initial diagnosis, new genetic variants were detected. We speculate that mutations with WT1 (R394fs/A387fs)/PTPN11 T73I/ETV6 S350P and JAK2 W659R may be related to relapse and chemotherapy resistance.
Publish Date	2022-12-14 07:20
Citation	Wang SL. Genetic changes in refractory relapsed acute myeloid leukemia with NPM1 mutation: A case report. World J Clin Cases 2022; 10(35): 13058-13063
URL	https://www.wjgnet.com/2307-8960/full/v10/i35/13058.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i35.13058

Full Article (PDF)	WJCC-10-13058.pdf
Full Article (Word)	WJCC-10-13058.docx
CARE Checklist–2016	79720-CARE-Checklist–2016-revision.pdf
Manuscript File	79720_Auto_Edited-JLW.docx
Answering Reviewers	79720-Answering reviewers.pdf
Audio Core Tip	79720-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	79720-Conflict-of-interest statement.pdf
Copyright License Agreement	79720-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	79720-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	79720-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	79720-Language certificate.pdf
Peer-review Report	79720-Peer-review(s).pdf
Scientific Misconduct Check	79720-Bing-Wang LL-2.png
Scientific Editor Work List	79720-Scientific editor work list.pdf
CrossCheck Report	79720-CrossCheck report.pdf