Publication Name	World Journal of Clinical Cases
Manuscript ID	79720
Country	China

Received	2022-09-05 16:08
Peer-Review Started	2022-09-05 16:11
To Make the First Decision
Return for Revision	2022-10-27 00:39
Revised	2022-11-04 16:32
Second Decision	2022-11-18 03:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-11-18 08:32
Articles in Press	2022-11-18 08:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-11-28 05:47
Publish the Manuscript Online	2022-12-14 07:20

ISSN	2307-8960 (online)
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Category	Hematology
Manuscript Type	Case Report
Article Title	Genetic changes in refractory relapsed acute myeloid leukemia with NPM1 mutation: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Shuang-Ling Wang
ORCID	Author(s) ORCID Number Shuang-Ling Wang http://orcid.org/0000-0003-3405-611X
Funding Agency and Grant Number	Funding Agency Grant Number Shantou Science and Technology Planning Project of Guangdong Province SFK [2019] 79
Corresponding Author	Shuang-Ling Wang, MMed, Doctor, Department of Hematology and Oncology, The Second Affiliated Hospital of Medical College of Shantou University, No. 69 Dongxia North Road, Shantou 515041, Guangdong Province, China. slwang_2006@126.com
Key Words	Acute myeloid leukemia; NPM1 mutation; Genetic variants; WT1; Case report
Core Tip	We report a patient with relapsed refractory acute myelomonocytic leukemia. Compared with the gene spectrum at initial diagnosis, new genetic variants were detected. We speculate that mutations with WT1 (R394fs/A387fs)/PTPN11 T73I/ETV6 S350P and JAK2 W659R may be related to relapse and chemotherapy resistance.
Publish Date	2022-12-14 07:20
Citation	Wang SL. Genetic changes in refractory relapsed acute myeloid leukemia with NPM1 mutation: A case report. World J Clin Cases 2022; 10(35): 13058-13063
URL	https://www.wjgnet.com/2307-8960/full/v10/i35/13058.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i35.13058

Full Article (PDF)	WJCC-10-13058.pdf
Full Article (Word)	WJCC-10-13058.docx
CARE Checklist–2016	79720-CARE-Checklist–2016-revision.pdf
Manuscript File	79720_Auto_Edited-JLW.docx
Answering Reviewers	79720-Answering reviewers.pdf
Audio Core Tip	79720-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	79720-Conflict-of-interest statement.pdf
Copyright License Agreement	79720-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	79720-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	79720-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	79720-Language certificate.pdf
Peer-review Report	79720-Peer-review(s).pdf
Scientific Misconduct Check	79720-Bing-Wang LL-2.png
Scientific Editor Work List	79720-Scientific editor work list.pdf