Publication Name	World Journal of Gastroenterology
Manuscript ID	79733
Country	Australia

Received	2022-09-04 10:03
Peer-Review Started	2022-09-04 10:05
To Make the First Decision
Return for Revision	2022-09-19 05:14
Revised	2022-09-21 22:43
Second Decision	2022-09-26 03:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-10-02 04:32
Articles in Press	2022-10-02 04:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-10-10 08:03
Publish the Manuscript Online	2022-10-18 08:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	COVID-19 and hepatorenal syndrome
Manuscript Source	Invited Manuscript
All Author List	Henry H L Wu, Varinder S Athwal, Philip A Kalra and Rajkumar Chinnadurai
ORCID	Author(s) ORCID Number Henry H L Wu http://orcid.org/0000-0002-4561-0844 Varinder S Athwal http://orcid.org/0000-0002-1684-721X Philip A Kalra http://orcid.org/0000-0001-7652-1572 Rajkumar Chinnadurai http://orcid.org/0000-0003-3973-6595
Funding Agency and Grant Number
Corresponding Author	Henry H L Wu, MBChB, Academic Editor, Academic Fellow, Doctor, Doctor, Honorary Research Fellow, Renal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, Reserve Road, 2065 St. Leonards NSW, Sydney 2065, New South Wales, Australia. honlinhenry.wu@health.nsw.gov.au
Key Words	COVID-19; Hepatorenal syndrome; Pathophysiology; Clinical assessment; Management; Prognosis
Core Tip	There have been numerous reviews evaluating the causative relationship between coronavirus disease 2019 (COVID-19) and liver pathology, given an emerging number of cases reporting COVID-19 induced liver injury. There are few reports noting the onset of hepatorenal syndrome (HRS) in the face of COVID-19 infection. Occurrence of HRS in any circumstance is typically an indicator of severe and perhaps life-threatening disease, potentially requiring liver transplantation. With a paucity in literature compilation on the associations between COVID-19 and HRS, we provide a review which discusses the purported pathophysiological mechanisms of COVID-19 induced HRS, and propose clinical assessment and management approaches in this scenario.
Publish Date	2022-10-18 08:29
Citation	Wu HHL, Athwal VS, Kalra PA, Chinnadurai R. COVID-19 and hepatorenal syndrome. World J Gastroenterol 2022; 28(39): 5666-5678
URL	https://www.wjgnet.com/1007-9327/full/v28/i39/5666.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i39.5666

Full Article (PDF)	WJG-28-5666.pdf
Full Article (Word)	WJG-28-5666.docx
Manuscript File	79733_Auto_Edited-LM.docx
Answering Reviewers	78567-Answering reviewers.pdf
Audio Core Tip	79733-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	79733-Conflict-of-interest statement.pdf
Copyright License Agreement	79733-Copyright license agreement.pdf
Peer-review Report	79733-Peer-review(s).pdf
Scientific Misconduct Check	79733-Bing-Chen YL-2.png
Scientific Editor Work List	79733-Scientific editor work list.pdf
CrossCheck Report	79733-CrossCheck report.pdf