Publication Name	World Journal of Gastroenterology
Manuscript ID	7984
Country	Türkiye

Received	2013-12-11 08:21
Peer-Review Started	2013-12-11 11:48
To Make the First Decision	2014-01-15 16:51
Return for Revision	2014-01-20 18:22
Revised	2014-02-11 15:33
Second Decision	2014-04-09 08:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-09 09:07
Articles in Press	2014-05-23 09:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-22 09:03
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Controlled Trial
Article Title	Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats
Manuscript Source	Invited Manuscript
All Author List	Sami Akbulut, Hulya Elbe, Cengiz Eris, Zumrut Dogan, Gulten Toprak, Emrah Otan, Erman Erdemli and Yusuf Turkoz
Funding Agency and Grant Number
Corresponding Author	Sami Akbulut, Assistant Professor, FICS, FACS, Liver Transplant Institute, Inonu University Faculty of Medicine, 44280 Malatya, Turkey. akbulutsami@gmail.com
Key Words	Methotrexate; Amifostine; N-acetyl cysteine; Ascorbic acid; Hepatotoxicity; Oxidative stress
Core Tip	While the underlying mechanism of methotrexate (MTX)-induced hepatotoxicity remains to be fully elucidated, increases in oxidative stress have been linked to the effects of MTX; moreover, MTX-induced toxicity has been shown to be associated with increases in lipid peroxidation in various tissues, such as liver, using rat model systems. A few previous studies have shown that prophylactic delivery of antioxidant agents can prevent MTX-induced hepatotoxicity. Based on this information, we aimed to investigate the role of oxidative stress in MTX-induced hepatotoxicity and to evaluate the potential therapeutic effects of the cytoprotective antioxidants N-acetylcysteine, amifostine, and ascorbic acid.
Publish Date	2014-08-07 10:34
Citation	Akbulut S, Elbe H, Eris C, Dogan Z, Toprak G, Otan E, Erdemli E, Turkoz Y. Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats. World J Gastroenterol 2014; 20(29): 10158-10165
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/10158.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.10158

Full Article (PDF)	WJG-20-10158.pdf
Full Article (Word)	WJG-20-10158.doc
Manuscript File	7984-Review.doc
Answering Reviewers	7984-Answering reviewers.pdf
Copyright License Agreement	7984-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7984-Language certificate.pdf
Peer-review Report	7984-Peer review(s).pdf
Scientific Editor Work List	7984-Scientific editor work list.doc