Publication Name	World Journal of Gastroenterology
Manuscript ID	7997
Country	Hungary

Received	2013-12-11 08:52
Peer-Review Started	2013-12-11 15:44
To Make the First Decision	2014-01-15 13:38
Return for Revision	2014-01-20 18:29
Revised	2014-02-07 20:21
Second Decision	2014-04-09 08:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-09 09:07
Articles in Press	2014-05-23 09:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-16 11:04
Publish the Manuscript Online	2014-07-21 17:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Retrospective Study
Article Title	Relevance of α-defensins (HNP1-3) and defensin β -1 in diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Balázs Csaba Németh, Tamás Várkonyi, Ferenc Somogyvári, Csaba Lengyel, Katalin Fehértemplomi, Szabolcs Nyiraty, Péter Kempler and Yvette Mándi
Funding Agency and Grant Number	Funding Agency Grant Number TÁMOP-4.2.2.A-11-1-KONV 2012-0035
Corresponding Author	Yvette Mándi, MD, PhD, DSc, Department of Medical Microbiology and Immunobiology, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary. mandi.yvette@med.u-szeged.hu
Key Words	α-defensins; HNP1-3; β-defensin 1; Diabetes; Copy number polymorphism; Single nucleotide polymorphism
Core Tip	There is growing evidence of the role of innate immunity in diabetes To our knowledge our data provide the first report on a complex investigation of defensin-α and defensin β-1 in type 1 and type 2 diabetes. The main conclusion of our manuscript is, that the elevated HNP1-3 levels in diabetes are independent of the DEFA1/DEFA3 copy numbers, but the GG genotype of C-44G SNP in the DEFB1 gene may result in a decreased level of defensin β-1 production. Our data support the view that both alpha and beta-defensins may have an important role in the pathogenesis of diabetes and diabetic complications.
Publish Date	2014-07-21 17:17
Citation	Németh BC, Várkonyi T, Somogyvári F, Lengyel C, Fehértemplomi K, Nyiraty S, Kempler P, Mándi Y. Relevance of α-defensins (HNP1-3) and defensin b-1 in diabetes. World J Gastroenterol 2014; 20(27): 9128-9137
URL	http://www.wjgnet.com/1007-9327/full/v20/i27/9128.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i27.9128

Full Article (PDF)	WJG-20-9128.pdf
Full Article (Word)	WJG-20-9128.doc
Manuscript File	7997-Review.doc
Answering Reviewers	7997-Answering reviewers.pdf
Copyright License Agreement	7997-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131210043823.JPG
Non-Native Speakers of English Editing Certificate	7997-Language certificate.pdf
Peer-review Report	7997-Peer review(s).pdf
Scientific Editor Work List	7997-Scientific editor work list.doc