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Articles Published Processes
8/25/2014 5:12:00 PM | Browse: 1341 | Download: 1727
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Received |
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2013-12-11 08:52 |
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Peer-Review Started |
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2013-12-11 15:44 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-01-20 18:29 |
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Revised |
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2014-02-07 20:21 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-04-09 08:19 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-04-09 09:07 |
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Articles in Press |
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2014-05-23 09:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-06-16 11:04 |
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Publish the Manuscript Online |
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2014-07-21 17:17 |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Retrospective Study |
| Article Title |
Relevance of α-defensins (HNP1-3) and defensin β -1 in diabetes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Balázs Csaba Németh, Tamás Várkonyi, Ferenc Somogyvári, Csaba Lengyel, Katalin Fehértemplomi, Szabolcs Nyiraty, Péter Kempler and Yvette Mándi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| TÁMOP-4.2.2.A-11-1-KONV |
2012-0035 |
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| Corresponding Author |
Yvette Mándi, MD, PhD, DSc, Department of Medical Microbiology and Immunobiology, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary. mandi.yvette@med.u-szeged.hu |
| Key Words |
α-defensins; HNP1-3; β-defensin 1; Diabetes; Copy number polymorphism; Single nucleotide polymorphism |
| Core Tip |
There is growing evidence of the role of innate immunity in diabetes To our knowledge our data provide the first report on a complex investigation of defensin-α and defensin β-1 in type 1 and type 2 diabetes. The main conclusion of our manuscript is, that the elevated HNP1-3 levels in diabetes are independent of the DEFA1/DEFA3 copy numbers, but the GG genotype of C-44G SNP in the DEFB1 gene may result in a decreased level of defensin β-1 production. Our data support the view that both alpha and beta-defensins may have an important role in the pathogenesis of diabetes and diabetic complications. |
| Publish Date |
2014-07-21 17:17 |
| Citation |
Németh BC, Várkonyi T, Somogyvári F, Lengyel C, Fehértemplomi K, Nyiraty S, Kempler P, Mándi Y. Relevance of α-defensins (HNP1-3) and defensin b-1 in diabetes. World J Gastroenterol 2014; 20(27): 9128-9137 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i27/9128.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i27.9128 |
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