Publication Name	World Journal of Critical Care Medicine
Manuscript ID	80011
Country	United States

Received	2022-09-13 23:43
Peer-Review Started	2022-09-13 23:45
To Make the First Decision
Return for Revision	2022-10-21 02:40
Revised	2022-11-15 03:31
Second Decision	2022-11-30 03:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-11-30 21:33
Articles in Press	2022-11-30 21:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-12-02 02:59
Publish the Manuscript Online	2023-01-03 10:13

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Critical Care Medicine
Manuscript Type	Systematic Reviews
Article Title	Clonidine use during dexmedetomidine weaning: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Sanu Rajendraprasad, Molly Wheeler, Erin Wieruszewski, Joseph Gottwald, Lindsey A. Wallace, Danielle Gerberi, Patrick M Wieruszewski and Nathan J Smischney
ORCID	Author(s) ORCID Number Patrick M Wieruszewski http://orcid.org/0000-0002-5871-5186 Nathan J Smischney http://orcid.org/0000-0003-1051-098X
Funding Agency and Grant Number
Corresponding Author	Nathan J Smischney, MD, MS, Associate Professor, Department of Anesthesiology & Perioperative Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States. smischney.nathan@mayo.edu
Key Words	Clonidine; Dexmedetomidine; Intensive care unit; Withdrawal; Weaning
Core Tip	In this systematic review of enteral clonidine use during dexmedetomidine weaning in critically ill patients, an association of increased withdrawal symptoms and agitation with the use of a clonidine taper and no difference in intensive care unit length of stay with or without clonidine taper was observed. However, varied techniques and a small total sample size restrict utility of the findings.
Publish Date	2023-01-03 10:13
Citation	Rajendraprasad S, Wheeler M, Wieruszewski E, Gottwald J, Wallace LA, Gerberi D, Wieruszewski PM, Smischney NJ. Clonidine use during dexmedetomidine weaning: A systematic review. World J Crit Care Med 2023; 12(1): 18-28
URL	https://www.wjgnet.com/2220-3141/full/v12/i1/18.htm
DOI	https://dx.doi.org/10.5492/wjccm.v12.i1.18

Full Article (PDF)	WJCCM-12-18.pdf
Full Article (Word)	WJCCM-12-18.docx
PRISMA 2009 Checklist	80011-PRISMA-2009-Checklist-revision.docx
Manuscript File	80011_Auto_Edited-LM.docx
Answering Reviewers	80011-Answering reviewers.pdf
Audio Core Tip	80011-Audio core tip.m4a
Biostatistics Review Certificate	80011-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	80011-Conflict-of-interest statement.pdf
Copyright License Agreement	80011-Copyright license agreement.pdf
Supplementary Material	80011-Supplementary materials.pdf
Peer-review Report	80011-Peer-review(s).pdf
Scientific Editor Work List	80011-Scientific editor work list.pdf
CrossCheck Report	80011-CrossCheck report.pdf