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Articles Published Processes
1/20/2023 1:48:20 PM | Browse: 325 | Download: 654
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Received |
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2022-09-15 11:15 |
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Peer-Review Started |
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2022-09-15 11:17 |
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To Make the First Decision |
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Return for Revision |
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2022-11-26 09:26 |
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Revised |
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2022-12-03 13:23 |
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Second Decision |
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2022-12-27 03:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-12-27 19:40 |
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Articles in Press |
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2022-12-27 19:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-01-05 21:15 |
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Typeset the Manuscript |
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2023-01-12 08:40 |
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Publish the Manuscript Online |
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2023-01-20 13:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Cytotoxic synergism of Clostridioides difficile toxin B with proinflammatory cytokines in subjects with inflammatory bowel diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gabrio Bassotti, Alessandro Fruganti, Fabrizio Stracci, Pierfrancesco Marconi and Katia Fettucciari |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Gabrio Bassotti, MD, PhD, Associate Professor, Department of Medicine, Gastroenterology and Hepatology Section, University of Perugia Medical School, Piazza Lucio Severi, San Sisto 06156, Italy. gabassot@tin.it |
| Key Words |
Inflammatory bowel diseases; Clostridioides difficile infection; Cytokines; Tumour necrosis factor-alpha; Interferon-gamma; necrosis; Apoptosis; Cytotoxic synergism |
| Core Tip |
Clostridioides difficile (C. difficile) is an opportunistic pathogen which diffusion is progressively increasing worldwide. Among the categories at risk, particularly susceptible are patients with inflammatory bowel diseases, due to altered immunological status and the therapies adopted that favour intestinal dysbiosis and colonization by the germ. Recent in vitro studies also suggest that the infection might be favoured by the strong cytotoxic synergism between C. difficile toxin B and pro-inflammatory cytokines tumour necrosis factor-a and interferon-g. The therapeutic approaches are however still limited, and those presently available rely on antibiotic therapy and faecal transplantation. |
| Publish Date |
2023-01-20 13:48 |
| Citation |
Bassotti G, Fruganti A, Stracci F, Marconi P, Fettucciari K. Cytotoxic synergism of Clostridioides difficile toxin B with proinflammatory cytokines in subjects with inflammatory bowel diseases. World J Gastroenterol 2023; 29(4): 582-596 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i4/582.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i4.582 |
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