Publication Name	World Journal of Clinical Oncology
Manuscript ID	8006
Country	Argentina

Received	2013-12-11 09:58
Peer-Review Started	2013-12-11 18:13
To Make the First Decision	2014-01-16 08:13
Return for Revision	2014-01-17 13:14
Revised	2014-01-21 04:08
Second Decision	2014-04-03 10:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-03 11:00
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-22 17:25
Publish the Manuscript Online	2014-08-01 16:16

ISSN	2218-4333 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Alcohol drinking and mammary cancer: Pathogenesis and potential dietary preventive alternatives
Manuscript Source	Invited Manuscript
All Author List	Gerardo Daniel Castro and José A Castro
Funding Agency and Grant Number
Corresponding Author	José A Castro, PhD, Professor of Toxicology, Centro de Investigaciones Toxicológicas, CITEDEF, Juan B. de La Salle 4397, B1603ALO Villa Martelli, Province of Buenos Aires, Argentina. jcastro@unsam.edu.ar
Key Words	Alcohol; Ethanol; Acetaldehyde; Free radicals; Mammary cancer; Oxidative stress; Estrogens; Polyphenols
Core Tip	Excessive alcohol drinking of any type of alcoholic beverage is known to linearly increase the risk of breast cancer. The precise mechanism involved to produce this effect is still far from being established. In this review we introduce our present working hypothesis integrating the participation in cancer initiation and promotion of: in situ accumulation of the acetaldehyde metabolite, the local promotion of oxidative stress and the effects of the increased levels of estrogen occurring during alcohol drinking. Some potential preventive alternatives were also analyzed.
Publish Date	2014-08-01 16:16
Citation	Castro GD, Castro JA. Alcohol drinking and mammary cancer: Pathogenesis and potential dietary preventive alternatives. World J Clin Oncol 2014; 5(4): 713-729
URL	http://www.wjgnet.com/2218-4333/full/v5/i4/713.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i4.713

Full Article (PDF)	WJCO-5-713.pdf
Full Article (Word)	WJCO-5-713.doc
Manuscript File	8006-Review.doc
Answering Reviewers	8006-Answering reviewers.pdf
Copyright License Agreement	8006-Copyright assignment.pdf
Peer-review Report	8006-Peer review(s).pdf
Scientific Editor Work List	8006-Scientific editor work list.doc