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Articles Published Processes
2/15/2023 12:44:08 AM | Browse: 246 | Download: 716
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Received |
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2022-09-19 09:04 |
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Peer-Review Started |
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2022-09-19 09:06 |
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To Make the First Decision |
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Return for Revision |
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2022-12-02 02:06 |
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Revised |
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2022-12-15 15:11 |
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Second Decision |
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2023-01-09 04:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-01-10 00:15 |
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Articles in Press |
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2023-01-10 00:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-02-07 06:40 |
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Publish the Manuscript Online |
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2023-02-15 00:44 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Role of ferroptosis in colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ya-Qi Song, Xiao-Dan Yan, Yi Wang, Zhen-Zhen Wang, Xin-Li Mao, Li-Ping Ye and Shao-Wei Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical Health Science and Technology Project of Zhejiang Province |
2021PY083 |
| Program of Taizhou Science and Technology Grant |
22ywb09 |
| Key Technology Research and Development Program of Zhejiang Province |
2019C03040 |
| Major Research Program of Taizhou Enze Medical Center Grant |
19EZZDA2 |
| Program of Taizhou Science and Technology Grant |
1901ky18 |
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| Corresponding Author |
Shao-Wei Li, PhD, Associate Professor, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, No. 150 Ximen Street, Linhai 317000, Zhejiang Province, China. li_shaowei81@hotmail.com |
| Key Words |
Ferroptosis; Colorectal cancer; System Xc−; Glutathione; Glutathione peroxidase 4 |
| Core Tip |
The prognosis of patients with advanced colorectal cancer is still poor, largely due to resistance to anticancer drugs. Ferroptosis is a novel form of non-apoptotic cell death, mainly characterized by abnormal iron metabolism and the excessive accumulation of lipid peroxidation. Studies have shown that ferroptosis can participate in the process of colorectal cancer (CRC) through the accumulation of lipid peroxides, inhibition of the System Xc−, disruption of the glutathione/glutathione peroxidase 4 balance, imbalance of iron homeostasis, and mediation of the P53 pathway. Induction of ferroptosis can reverse the resistance of anticancer drugs and improve the prognosis of CRC patients. |
| Publish Date |
2023-02-15 00:44 |
| Citation |
Song YQ, Yan XD, Wang Y, Wang ZZ, Mao XL, Ye LP, Li SW. Role of ferroptosis in colorectal cancer. World J Gastrointest Oncol 2023; 15(2): 225-239 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i2/225.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i2.225 |
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