| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Application of nanotechnology in reversing therapeutic resistance and controlling metastasis of colorectal cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Sheng-Nan Ren, Zhan-Yi Zhang, Rui-Jie Guo, Da-Ren Wang, Fang-Fang Chen, Xue-Bo Chen and Xue-Dong Fang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Jilin Province |
20210101433JC |
|
| Corresponding Author |
Xue-Bo Chen, MD, Doctor, Doctor, Professor, Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun 130033, Jilin Province, China. chenxb@jlu.edu.cn |
| Key Words |
Colorectal cancer; Therapeutic resistance; Nanotechnology; Drug delivery system; Combined treatment |
| Core Tip |
Mechanisms of Colorectal cancer (CRC) cell resistance can be attributed to tumoral and environmental factors, the former of which includes gene expression alteration, signaling pathway activation, metabolic rewiring, and the later refers to complicated adaptions regarding cancer associated fibroblast, immune cells, hypoxic conditions. Taking efforts to conquer therapeutic resistance is imperative to improve CRC patients` survival. Nanotechnology possesses distinct advantages to increase specificity of treatment and realize codelivery of multiple drugs, which facilitates to restore sensitivity to antitumor therapy, and modulate suppressive tumor microenvironment to stimulatory environment. |
| Publish Date |
2023-04-07 05:51 |
| Citation |
Ren SN, Zhang ZY, Guo RJ, Wang DR, Chen FF, Chen XB, Fang XD. Application of nanotechnology in reversing therapeutic resistance and controlling metastasis of colorectal cancer. World J Gastroenterol 2023; 29(13): 1911-1941 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i13/1911.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i13.1911 |
