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Articles Published Processes
3/17/2023 6:20:53 AM | Browse: 264 | Download: 732
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Received |
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2022-09-21 02:17 |
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Peer-Review Started |
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2022-09-21 02:19 |
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To Make the First Decision |
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Return for Revision |
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2022-11-05 06:09 |
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Revised |
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2023-01-05 20:38 |
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Second Decision |
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2023-03-03 03:29 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-03-07 18:23 |
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Articles in Press |
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2023-03-07 18:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-03-13 04:46 |
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Publish the Manuscript Online |
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2023-03-17 06:20 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Microbiome-liver crosstalk: A multihit therapeutic target for liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jorum Kirundi, Sheida Moghadamrad and Camilla Urbaniak |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Camilla Urbaniak, PhD, Research Scientist, Senior Scientist, Biotechnology and Planetary Protection Group, NASA Jet Propulsion Laboratory , 4800 Oak Grove Dr, Pasadena 91109, California, Uruguay. camilla.urbaniak@jpl.nasa.gov |
| Key Words |
Microbiome; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Liver disease; Microbiome-host crosstalk; Gut homeostasis; Microbial metabolites |
| Core Tip |
The influence of the gut microbiome on various body systems has important implications for health and disease, such as liver disease. While the exact mechanisms of how the microbiome contributes to liver disease are unknown, there is strong evidence that the translocation of various metabolites across the mucosal barrier plays a strong role, which is precipitated by dysbiotic gut microbiota. Considering the importance of the microbiome in liver disease, powerful therapeutic options that can manipulate the gut microbiome are being explored. These approaches could have the potential for effective treatments for various stages of liver disease. This review will explore how the mechanisms of colonization resistance influence the liver in health and disease and finally examine potential therapeutic targets in the gut-liver axis. |
| Publish Date |
2023-03-17 06:20 |
| Citation |
Kirundi J, Moghadamrad S, Urbaniak C. Microbiome-liver crosstalk: A multihit therapeutic target for liver disease. World J Gastroenterol 2023; 29(11): 1651-1668 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i11/1651.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i11.1651 |
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