Publication Name	World Journal of Gastroenterology
Manuscript ID	8029
Country	China

Received	2013-12-12 16:11
Peer-Review Started	2013-12-12 18:19
First Decision by Editorial Office Director
Return for Revision	2014-01-20 18:39
Revised	2014-02-24 08:26
Publication Fee Transferred
Second Decision by Editor	2014-05-26 16:21
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-26 16:44
Articles in Press	2014-05-26 17:38
Edit the Manuscript by Language Editor	2014-06-09 18:51
Typeset the Manuscript	2014-08-15 17:46
Publish the Manuscript Online	2014-08-29 11:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Decreased expression of miR-133a correlates with poor prognosis in colorectal cancer patients
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Li Wang, Lu-Tao Du, Juan Li, Yi-Min Liu, Ai-Lin Qu, Yong-Mei Yang, Xin Zhang, Gui-Xi Zheng and Chuan-Xin Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Key Clinical Medical Specialties Foundation and the National Natural Science Foundation of China 81271916 National Key Clinical Medical Specialties Foundation and the National Natural Science Foundation of China 81301506
Corresponding Author	Correspondence to: Chuan-Xin Wang, MD, PhD, Department of Clinical Laboratory, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, Shandong Province, China. cxwang@sdu.edu.cn
Key Words	Colorectal cancer; Biomarker; MicroRNA-133a; Prognosis; Real-time polymerase chain reaction
Core Tip	In the present study, the level of microRNA-133a (miR-133a) was found to be downregulated in colorectal cancer (CRC) tissues. The altered expression of miR-133a was significantly associated with malignant behavior, including tumor cell differentiation, local invasion, lymph node metastasis and tumor-node-metastasis stage. Multivariate analysis suggested that low expression of miR-133a is an independent prognostic factor for CRC. Furthermore, the data suggest that miR-133a may play a critical role in CRC progression, and thus may serve as a potential therapeutic target.
Publish Date	2014-08-29 11:57
Citation	Wang LL, Du LT, Li J, Liu YM, Qu AL, Yang YM, Zhang X, Zheng GX, Wang CX. Decreased expression of miR-133a correlates with poor prognosis in colorectal cancer patients. World J Gastroenterol 2014; 20(32): 11340-11346
URL	http://www.wjgnet.com/1007-9327/full/v20/i32/11340.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i32.11340

Full Article (PDF)	WJG-20-11340.pdf
Full Article (Word)	WJG-20-11340.doc
Manuscript File	8029-Review.doc
Answering Reviewers	8029-Answering reviewers.pdf
Copyright License Agreement	8029-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	AMEpc3080_locked for submission_with figures.doc
Peer-review Report	8029-Peer review(s).pdf
Scientific Misconduct Check	8029-CrossCheck.jpg
Scientific Editor Work List	8029-Scientific editor work list.pdf