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Articles Published Processes
2/14/2023 12:24:40 PM | Browse: 321 | Download: 591
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Received |
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2022-10-06 03:21 |
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Peer-Review Started |
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2022-10-06 03:24 |
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To Make the First Decision |
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Return for Revision |
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2022-11-18 07:56 |
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Revised |
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2022-12-13 21:33 |
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Second Decision |
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2023-01-16 03:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-01-17 06:26 |
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Articles in Press |
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2023-01-17 06:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-01-04 00:03 |
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Typeset the Manuscript |
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2023-02-02 08:27 |
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Publish the Manuscript Online |
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2023-02-14 12:24 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Review |
| Article Title |
Insulin: A connection between pancreatic β cells and the hypothalamus
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Brenda De la Cruz Concepción, Yaccil Adilene Flores Cortez, Martha Isela Barragán Bonilla, Juan Miguel Mendoza Bello and Monica Espinoza Rojo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Monica Espinoza Rojo, PhD, Researcher, Molecular and Genomic Biology Laboratory, , Chilpancingo 39070, Guerrero, Mexico., Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Av. Lázaro Cárdenas S/N, Ciudad Universitaria, Chilpancingo 39090, Guerrero, Mexico. monicaespinoza@uagro.mx |
| Key Words |
Insulin; Pancreas; Hypothalamus; Hyperphagia; Hyperglycemia; Stress |
| Core Tip |
Insulin is the connection between the β cells of the pancreas and the hypothalamus. Insulin reaches the arcuate nucleus of the hypothalamus and represses the expression of orexigenic neuropeptides to suppress appetite. However, its function decreases when there is damage to the β cells of the pancreas. Its anorexigenic effect decreases and thus increases appetite. The excess of nutrients, specifically carbohydrates, aggravates the damage to β cells and induces obesity and/or diabetes and oxidative damage. The use of antioxidants constitutes a therapeutic approach that has been approached experimentally to regulate the negative effects of alterations in insulin secretion and function. |
| Publish Date |
2023-02-14 12:24 |
| Citation |
De la Cruz Concepción B, Flores Cortez YA, Barragán Bonilla MI, Mendoza Bello JM, Espinoza Rojo M. Insulin: A connection between pancreatic β cells and the hypothalamus. World J Diabetes 2023; 14(2): 76-91 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i2/76.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i2.76 |
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