| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Liver infiltration of multiple immune cells during the process of acute liver injury and repair
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yuan Xie, Ke-Bo Zhong, Yang Hu, Yong-Lun Xi, Shi-Xing Guan, Meng Xu, Yuan Lin, Feng-Yong Liu, Wei-Jie Zhou and Yi Gao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Key R&D Program of China |
2018YFA0108200 |
| the National Key R&D Program of China |
2018YFC1106400 |
| the National Natural Science Foundation of China |
31972926 |
| Guangdong Basic and Applied Basic Research Foundation |
2020A1515111111 |
|
| Corresponding Author |
Yi Gao, MD, Doctor, General Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, No. 253 Gongye Middle Avenue, Haizhu District, Guangzhou 510280, Guangdong Province, China. gaoyi6146@163.com |
| Key Words |
Immune cells; Liver injury; Liver repair; Leukocyte cell-derived chemotaxin 2 |
| Core Tip |
In our study, we systematically described the infiltration changes of various immune cells during the process of acute liver injury and repair. We found that the recovery time of immune cells was far behind that of serum alanine transaminase and aspartate transaminase during the process of liver repair. Moreover, we found that leukocyte cell-derived chemotaxin 2 (LECT2) was upregulated in acute liver injury mouse models and the changes in LECT2 were related to the changes in several immune cells. LECT2 could regulate monocyte/macrophage chemotaxis and might be used as a therapeutic target for acute liver injury. |
| Publish Date |
2022-12-08 09:04 |
| Citation |
Xie Y, Zhong KB, Hu Y, Xi YL, Guan SX, Xu M, Lin Y, Liu FY, Zhou WJ, Gao Y. Liver infiltration of multiple immune cells during the process of acute liver injury and repair. World J Gastroenterol 2022; 28(46): 6537-6550 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i46/6537.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i46.6537 |
