Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	80448
Country	South Korea

Received	2022-09-28 07:48
Peer-Review Started	2022-09-28 07:51
To Make the First Decision
Return for Revision	2022-12-14 02:41
Revised	2022-12-18 02:43
Second Decision	2023-01-09 04:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-09 23:21
Articles in Press	2023-01-09 23:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-02-07 06:42
Publish the Manuscript Online	2023-02-15 00:44

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Editorial
Article Title	Challenges to addressing the unmet medical needs for immunotherapy targeting cold colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Keun-Yeong Jeong
ORCID	Author(s) ORCID Number Keun-Yeong Jeong http://orcid.org/0000-0002-4933-3493
Funding Agency and Grant Number
Corresponding Author	Keun-Yeong Jeong, PhD, Chief Technician, Founder and CEO, Research and Development Center, PearlsinMires, 120 Geobukgol-ro, Seodaemun-gu, Seoul 03690, South Korea. alvirus@naver.com
Key Words	Colorectal cancer; Immunotherapy; Cell therapy; Checkpoint inhibitor; Cancer vaccine; Cytokine therapy
Core Tip	There have been continuing attempts to treat colorectal cancer (CRC) with immunotherapies, and various methods of converting cold into hot tumors have gone through trial and error up to now. Based on this background, this editorial introduces the concept of cold CRC and various strategies across non-clinical and clinical for enhancing immunotherapeutic efficacy and further encourages the journey to an advanced level of immunotherapies targeting cold CRC.
Publish Date	2023-02-15 00:44
Citation	Jeong KY. Challenges to addressing the unmet medical needs for immunotherapy targeting cold colorectal cancer. World J Gastrointest Oncol 2023; 15(2): 215-224
URL	https://www.wjgnet.com/1948-5204/full/v15/i2/215.htm
DOI	https://dx.doi.org/10.4251/wjgo.v15.i2.215

Full Article (PDF)	WJGO-15-215.pdf
Full Article (Word)	WJGO-15-215.docx
Manuscript File	80448_Auto_Edited-LM.docx
Answering Reviewers	80448-Answering reviewers.pdf
Audio Core Tip	80448-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	80448-Conflict-of-interest statement.pdf
Copyright License Agreement	80448-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	80448-Language certificate.pdf
Peer-review Report	80448-Peer-review(s).pdf
Scientific Misconduct Check	80448-Bing-Wang JJ-2.png
Scientific Editor Work List	80448-Scientific editor work list.pdf