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Articles Published Processes
3/10/2023 7:29:15 AM | Browse: 224 | Download: 414
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Received |
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2022-09-29 15:22 |
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Peer-Review Started |
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2022-09-29 15:24 |
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To Make the First Decision |
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Return for Revision |
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2023-01-03 21:06 |
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Revised |
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2023-01-17 11:10 |
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Second Decision |
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2023-02-10 03:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-02-22 00:46 |
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Articles in Press |
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2023-02-22 00:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-03-01 04:25 |
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Typeset the Manuscript |
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2023-03-07 08:32 |
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Publish the Manuscript Online |
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2023-03-10 07:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Precision medicine in inflammatory bowel disease: Individualising the use of biologics and small molecule therapies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Eric Cheah and James Guoxian Huang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
James Guoxian Huang, MBBS, Assistant Professor, Attending Doctor, Staff Physician, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore. james_huang@nuhs.edu.sg |
| Key Words |
Precision medicine; Therapeutic ceiling; Inflammatory bowel disease; Biologics; Small molecules |
| Core Tip |
Precision medicine and individualising patient care has been the holy grail in the management of inflammatory bowel disease (IBD). A one-size-fits-all approach, utilising the current armamentarium of biologics and small molecules, still yields less than ideal clinical outcomes, with significantly high non-response rates. Multiple challenges remain in breaking this therapeutic ceiling: achieving an early diagnosis of IBD ideally even in the pre-clinical phase, accurately prognosticating the disease course and tailoring an appropriately sequenced therapy regime to a patient disease severity, pharmacokinetic and pharmacodynamic profile. |
| Publish Date |
2023-03-10 07:29 |
| Citation |
Cheah E, Huang JG. Precision medicine in inflammatory bowel disease: Individualising the use of biologics and small molecule therapies. World J Gastroenterol 2023; 29(10): 1539-1550 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i10/1539.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i10.1539 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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