| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Role of noncoding RNAs in liver fibrosis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Qing-Yuan Li, Tao Gong, Yi-Ke Huang, Lan Kang, Charlotte A Warner, He Xie, Li-Min Chen and Xiao-Qiong Duan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Innovation Talent Project of Sichuan Province |
2022JDRC0047 |
| Central Government-directed Special Funds for Local Science and Technology Development Project |
2021ZYD0085 |
| Natural Science Foundation of China |
82102383 |
| Qin Chuangyuan Recruited High-level Innovation and Entrepreneurship Talents Project of Science and Technology Department of Shaanxi Province |
QCYRCXM-2022-56 |
|
| Corresponding Author |
Xiao-Qiong Duan, PhD, Associate Professor, Center for Transfusion-transmitted Infectious Diseases, Institute of Blood Transfusion,Chinese Academy of Medical Sciences and Peking Union Medical College, No. 26 Huacai Road, Chengdu 610052, Sichuan Province, China. xiaoqiongduan@163.com |
| Key Words |
MicroRNAs; Long noncoding RNAs; Circular RNAs; Liver fibrosis; Diagnosis; Treatment |
| Core Tip |
Liver fibrosis is an inevitable stage in the development of various chronic liver diseases, and manifests as an imbalance between the formation and degradation of extracellular matrix. The key mechanism of liver fibrosis is the activation of hepatic stellate cells, which is coordinately regulated by a variety of cytokines, inflammatory factors and chemokines involved in multiple cells signaling pathways. In this review, we discuss the role of noncoding RNAs (ncRNAs) in regulating the signaling pathways in the formation and regression of liver fibrosis, and the limitations, challenges, and prospects of ncRNAs in the diagnosis and treatment of liver fibrosis. |
| Publish Date |
2023-03-07 16:31 |
| Citation |
Li QY, Gong T, Huang YK, Kang L, Warner CA, Xie H, Chen LM, Duan XQ. Role of noncoding RNAs in liver fibrosis. World J Gastroenterol 2023; 29(9): 1446-1459 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i9/1446.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i9.1446 |
