| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Prostaglandin F2α synthase promotes oxaliplatin resistance in colorectal cancer through prostaglandin F2α-dependent and F2α-independent mechanism
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Jun Wang, Xiao-Li Xie, Hong-Qun Liu, Hui Tian, Xiao-Yu Jiang, Jiu-Na Zhang, Sheng-Xiong Chen, Ting Liu, Shu-Ling Wang, Xue Zhou, Xiao-Xu Jin, Shi-Mao Liu and Hui-Qing Jiang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the S and T Program of Hebei |
No. 22377704D |
| Postgraduate’s Innovation Fund Project of Hebei Province |
No. CXZZBS2021077 |
| Medical Science Research Project of Hebei Province, |
No. 20190510 |
|
| Corresponding Author |
Hui-Qing Jiang, Doctor, Chief Physician, Director, Director, Department of Gastroenterology, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China. jianghuiqing1959@sina.com |
| Key Words |
Prostaglandin F2α synthase; Colorectal cancer; Oxaliplatin; Drug resistance; DNA damage |
| Core Tip |
Prostaglandin F2α synthase (PGF2α) (PGFS) is an enzymatic catalyst responsible for the biosynthesis of PGF2α. Our study revealed that PGFS exerts an inhibitory effect on the generation of reactive oxygen species by means of its downstream product PGF2α, and consequently facilitates resistance to oxaliplatin in colorectal cancer. Simultaneously, PGFS suppresses the formation of platinum-DNA adducts in a manner that is not reliant on PGF2α, which is rarely reported. |
| Publish Date |
2023-10-19 16:26 |
| Citation |
Wang YJ, Xie XL, Liu HQ, Tian H, Jiang XY, Zhang JN, Chen SX, Liu T, Wang SL, Zhou X, Jin XX, Liu SM, Jiang HQ. Prostaglandin F2α synthase promotes oxaliplatin resistance in colorectal cancer through prostaglandin F2α-dependent and F2α-independent mechanism. World J Gastroenterol 2023; 29(39): 5452-5470 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i39/5452.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i39.5452 |
