Publication Name	World Journal of Gastroenterology
Manuscript ID	8067
Country	Belgium

Received	2013-12-15 15:40
Peer-Review Started	2013-12-16 08:38
First Decision by Editorial Office Director
Return for Revision	2014-01-20 18:53
Revised	2014-02-08 21:45
Publication Fee Transferred
Second Decision by Editor	2014-03-10 15:12
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-03-10 16:52
Articles in Press	2014-05-23 10:28
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-25 13:47
Publish the Manuscript Online	2014-08-18 16:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Human liver stem/progenitor cells decrease serum bilirubin in hyperbilirubinemic Gunn rat
Manuscript Source	Unsolicited Manuscript
All Author List	Cédric Maerckx, Tatiana Tondreau, Silvia Berardis, Jos van Pelt, Mustapha Najimi and Etienne Sokal
Funding Agency and Grant Number	Funding Agency Grant Number Fonds pour la formation à la recherche dans l’industrie et dans l’agriculture
Corresponding Author	Etienne Sokal, MD, Professor of Medicine, Laboratory of Pediatric Hepatology and Cell Therapy, Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (iRCE), 52, Avenue Mounier - Tour Vésale +3, 1200 Brussels, Belgium. etienne.sokal@uclouvain.be
Key Words	Liver stem/progenitor cells; Gunn rat; Hepatocyte; in vitro and in situ differentiation; Uridine diphosphate-glucuronosyltransferase 1A1
Core Tip	In this study we demonstrated the ability of adult-derived human liver stem/progenitor cells (ADHLSC) to specifically conjugate bilirubin after intraportal injection into Gunn rats a model presenting a deficient bilirubin conjugation function (homologous to human Crigler-Najjar type Ⅰ syndrome). Infused-Gunn rats exhibited a metabolic effect 3 mo post-transplantation and maintained over a 6 mo period. ADHLSC engraftment into Gunn rat’s liver was demonstrated by immunohistochemistry and RTqPCR. These results suggest the potential of ADHLSC to restore a deficient metabolic function in situ.
Publish Date	2014-08-18 16:49
Citation	Maerckx C, Tondreau T, Berardis S, van Pelt J, Najimi M, Sokal E. Human liver stem/progenitor cells decrease serum bilirubin in hyperbilirubinemic Gunn rat. World J Gastroenterol 2014; 20(30): 10553-10563
URL	http://www.wjgnet.com/1007-9327/full/v20/i30/10553.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i30.10553

Full Article (PDF)	WJG-20-10553.pdf
Full Article (Word)	WJG-20-10553.doc
Manuscript File	8067-Review.doc
Answering Reviewers	8067-Answering reviewers.pdf
Copyright License Agreement	8067-Copyright assignment.pdf
Peer-review Report	8067-Peer review(s).pdf
Scientific Editor Work List	8067-Scientific editor work list.doc