Publication Name	World Journal of Orthopedics
Manuscript ID	80685
Country	China

Received	2022-10-09 11:31
Peer-Review Started	2022-10-09 11:33
To Make the First Decision
Return for Revision	2022-11-22 08:59
Revised	2022-12-01 08:22
Second Decision	2023-01-13 03:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-01-17 18:27
Articles in Press	2023-01-17 18:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-01-20 09:39
Publish the Manuscript Online	2023-02-17 15:13

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Infectious Diseases
Manuscript Type	Minireviews
Article Title	Diagnosis and treatment of chronic osteomyelitis based on nanomaterials
Manuscript Source	Invited Manuscript
All Author List	Ming Zeng, Zheng Xu, Zhen-Qi Song, Jie-Xiao Li, Zhong-Wen Tang, Sheng Xiao and Jie Wen
ORCID	Author(s) ORCID Number Ming Zeng http://orcid.org/0000-0002-2688-0291 Zhen-Qi Song http://orcid.org/0000-0002-9587-5082 Zhong-Wen Tang http://orcid.org/0000-0001-6201-4625 Sheng Xiao http://orcid.org/0000-0001-8595-7861 Jie Wen http://orcid.org/0000-0002-5734-4678
Funding Agency and Grant Number	Funding Agency Grant Number Science project of Hunan Provincial Health Commission 202204073347
Corresponding Author	Jie Wen, PhD, Associate Professor, Department of Pediatric Orthopedics, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 West Jiefang Road, Changsha 410013, Hunan Province, China. cashwj@qq.com
Key Words	Osteomyelitis; Nanomaterials; Infectious disease; Drug delivery
Core Tip	Chronic osteomyelitis is a painful and serious disease caused by infected surgical prostheses or infected fractures. Traditional treatment includes surgical debridement followed by prolonged systemic antibiotics treatment. But as antibiotics is difficult to penetrate into the internal infection areas of bone, thus limiting the efficacy of systemic antibiotic therapy, new therapeutic approach to treat this disease remains a major challenge for orthopedic surgeons. Substantial progress has been made in constructing antibacterial nanomaterials for treatment of chronic osteomyelitis. We review some current strategies for treatment of chronic osteomyelitis and their underlying mechanisms.
Publish Date	2023-02-17 15:13
Citation	Zeng M, Xu Z, Song ZQ, Li JX, Tang ZW, Xiao S, Wen J. Diagnosis and treatment of chronic osteomyelitis based on nanomaterials. World J Orthop 2023; 14(2): 42-54
URL	https://www.wjgnet.com/2218-5836/full/v14/i2/42.htm
DOI	https://dx.doi.org/10.5312/wjo.v14.i2.42

Full Article (PDF)	WJO-14-42.pdf
Full Article (Word)	WJO-14-42.docx
Manuscript File	80685_Auto_Edited-LM.docx
Answering Reviewers	80685-Answering reviewers.pdf
Audio Core Tip	80685-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	80685-Conflict-of-interest statement.pdf
Copyright License Agreement	80685-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	80685-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	80685-Language certificate.pdf
Supplementary Material	80685-Supplementary material.pdf
Peer-review Report	80685-Peer-review(s).pdf
Scientific Misconduct Check	80685-Bing-Wang JJ-2.png
Scientific Editor Work List	80685-Scientific editor work list.pdf
CrossCheck Report	80685-CrossCheck report.pdf