Publication Name	World Journal of Gastroenterology
Manuscript ID	8082
Country	India

Received	2013-12-15 16:43
Peer-Review Started	2013-12-16 09:31
To Make the First Decision	2014-02-14 15:31
Return for Revision	2014-02-18 10:57
Revised	2014-03-13 18:29
Second Decision	2014-05-26 16:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-26 16:45
Articles in Press	2014-05-26 17:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-30 10:30
Publish the Manuscript Online	2014-09-18 19:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Evidence-Based Medicine
Article Title	Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Shafqat A Khan, Monica Tyagi, Ajit K Sharma, Savio G Barreto, Bhawna Sirohi, Mukta Ramadwar, Shailesh V Shrikhande and Sanjay Gupta
Funding Agency and Grant Number	Funding Agency Grant Number TMH-IRG 466 Advanced Center for Treatment Research and Education in Cancer, India for funding to Gupta lab
Corresponding Author	Sanjay Gupta, PhD, Principal Investigator, Scientific Officer “F”, Epigenetics and Chromatin Biology Group, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, MH 410210, India. sgupta@actrec.gov.in
Key Words	Gastric cancer; β-actin; Immunohistochemistry; Epithelial cells; Inflammatory cells; Tumor infiltrating immune cells; Adjacent mucosa; Resection margin
Core Tip	Clinical implications of β-actin have been ignored despite the reports of its differential expression in cancer. The present study provides first histological evidence of an overall increase in β-actin expression in gastric cancer compared to histologically normal adjacent mucosa. Inflammatory and epithelial cells of tumor tissues showed differential pattern of β-actin expression and correlated with tumor grade. Further, overexpression of β-actin was predominantly contributed by inflammatory cells, suggesting further extensive studies to use beta-actin as a diagnostic and prognostic biomarker and target of direct or indirect chemotherapeutic intervention.
Publish Date	2014-09-18 19:50
Citation	Khan SA, Tyagi M, Sharma AK, Barreto SG, Sirohi B, Ramadwar M, Shrikhande SV, Gupta S. Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma. World J Gastroenterol 2014; 20(34): 12202-12211
URL	http://www.wjgnet.com/1007-9327/full/v20/i34/12202.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i34.12202

Full Article (PDF)	WJG-20-12202.pdf
Full Article (Word)	WJG-20-12202.doc
Manuscript File	8082-Review.doc
Answering Reviewers	8082-Answering reviewers.pdf
Copyright License Agreement	8082-Copyright assignment.pdf
Peer-review Report	8082-Peer review(s).pdf
Scientific Misconduct Check	8082-CrossCheck.jpg
Scientific Editor Work List	8082-Scientific editor work list.pdf