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Articles Published Processes
2/10/2023 9:15:29 AM | Browse: 211 | Download: 631
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Received |
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2022-10-16 14:39 |
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Peer-Review Started |
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2022-10-16 14:41 |
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To Make the First Decision |
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Return for Revision |
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2022-11-03 07:48 |
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Revised |
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2022-11-14 04:12 |
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Second Decision |
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2023-01-31 03:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-01-31 17:56 |
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Articles in Press |
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2023-01-31 17:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-02-01 07:51 |
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Publish the Manuscript Online |
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2023-02-10 09:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dentistry, Oral Surgery & Medicine |
| Manuscript Type |
Review |
| Article Title |
Periodontal treatment and microbiome-targeted therapy in management of periodontitis-related nonalcoholic fatty liver disease with oral and gut dysbiosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ryutaro Kuraji, Takahiko Shiba, Tien S Dong, Yukihiro Numabe and Yvonne L. Kapila |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| A Japanese Society of Periodontology (JSP) Seeds Young Investigator Research Grant 2021 |
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| A Japanese Society for the Promotion of Science (JSPS) KAKENHI Grant |
21K16980 |
| AAP Sunstar Innovation Grant |
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| NIH 2 R01 DE025225 grant |
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| Corresponding Author |
Ryutaro Kuraji, DDS, PhD, Associate Professor, Lecturer, Department of Periodontology, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20, Fujimi, Chiyoda-ku, Tokyo 102-0071, Japan. r-kuraji@tky.ndu.ac.jp |
| Key Words |
Periodontal disease; Nonalcoholic fatty liver disease; Microbiota; Dysbiosis; Metabolic syndrome; Probiotics |
| Core Tip |
A growing body of evidence from multiple areas highlights that periodontal disease, accompanied by oral inflammation and pathological changes in the microbiome, induces gut dysbiosis and is involved in the pathogenesis of Nonalcoholic fatty liver disease (NAFLD). Thus, the conventional periodontal treatment and microbiome-targeted therapies that include probiotics, prebiotics and bacteriocin would hold great promise for preventing the onset and progression of NAFLD. In this review, we will describe the link between periodontal disease and NAFLD with a focus on basic, epidemiological, and clinical studies, and discuss potential mechanisms linking the two diseases and possible therapeutic approaches focused on the microbiome. |
| Publish Date |
2023-02-10 09:15 |
| Citation |
Kuraji R, Shiba T, Dong TS, Numabe Y, Kapila YL. Periodontal treatment and microbiome-targeted therapy in management of periodontitis-related nonalcoholic fatty liver disease with oral and gut dysbiosis. World J Gastroenterol 2023; 29(6): 967-996 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i6/967.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i6.967 |
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