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Articles Published Processes
3/17/2023 6:20:53 AM | Browse: 451 | Download: 1773
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Received |
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2022-10-14 06:34 |
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Peer-Review Started |
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2022-10-14 06:35 |
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First Decision by Editorial Office Director |
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2023-01-03 20:42 |
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Return for Revision |
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2023-01-03 20:42 |
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Revised |
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2023-01-13 08:35 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-02-20 03:45 |
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Second Decision by Editor-in-Chief |
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2023-02-21 02:53 |
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Final Decision by Editorial Office Director |
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2023-02-27 22:14 |
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Articles in Press |
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2023-02-27 22:14 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-03-06 02:59 |
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Publish the Manuscript Online |
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2023-03-17 06:20 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Locked nucleic acid real-time polymerase chain reaction method identifying two polymorphisms of hepatitis B virus genotype C2 infections, rt269L and rt269I
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kijeong Kim, Yu-Min Choi, Dong Hyun Kim, Junghwa Jang, Won Hyeok Choe and Bum-Joon Kim |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea |
2022R1A2B5B01001421 |
| Korea Health Technology R&D Project through the Korea Health Industry Development Institute, the Ministry of Health & Welfare, Republic of Korea |
HI22C0476 |
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| Corresponding Author |
Bum-Joon Kim, PhD, Professor, Department of Microbiology and Immunology, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080, South Korea. kbumjoon@snu.ac.kr |
| Key Words |
Hepatitis B virus; Genotype C2; Polymerase; rt269; Locked nucleic acid-real time-polymerase chain reaction; Chronic hepatitis B |
| Core Tip |
Hepatitis B virus (HBV) genotype C2 infections have distinct clinical or virological traits, including a higher risk of hepatocellular carcinoma, lower response rate to interferon or prolonged hepatitis B e antigen-positive phase. We recently reported that the presence of two HBV Pol RT polymorphisms, rt269L and rt269I, contributed to unique traits of HBV genotype C2. Here, instead of time- or labor-consuming direct sequencing, we developed a new locked nucleic acid (LNA)-real time-polymerase chain reaction (RT-PCR) method for the separation between rt269L (L1 and L2) and I type from Korean chronic hepatitis B patients of genotype C2. The newly developed LNA-RT-PCR could be effectively used for the understanding of epidemiology and disease progression in genotype C2 endemic areas. |
| Publish Date |
2023-03-17 06:20 |
| Citation |
Kim K, Choi YM, Kim DH, Jang J, Choe WH, Kim BJ. Locked nucleic acid real-time polymerase chain reaction method identifying two polymorphisms of hepatitis B virus genotype C2 infections, rt269L and rt269I. World J Gastroenterol 2023; 29(11): 1721-1734 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i11/1721.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i11.1721 |
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