Publication Name	World Journal of Hepatology
Manuscript ID	80909
Country	China

Received	2022-10-17 11:53
Peer-Review Started	2022-10-17 11:55
To Make the First Decision
Return for Revision	2022-11-16 00:45
Revised	2022-11-26 03:15
Second Decision	2022-12-23 03:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-12-23 09:10
Articles in Press	2022-12-23 09:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-12-27 07:35
Publish the Manuscript Online	2023-01-16 06:02

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Prognostic role of ring finger and WD repeat domain 3 and immune cell infiltration in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Dong Miao, Wu-Xia Quan, Jiang-Tao Wang, Jian Gan, Xin Dong and Fang Zhang
ORCID	Author(s) ORCID Number Yan-Dong Miao http://orcid.org/0000-0002-1429-8915 Wu-Xia Quan http://orcid.org/0000-0002-1898-850X Jiang-Tao Wang http://orcid.org/0000-0002-1222-164X Jian Gan http://orcid.org/0000-0003-2645-6076 Xin Dong http://orcid.org/0000-0002-4318-3228 Fang Zhang http://orcid.org/0000-0001-5120-0991
Funding Agency and Grant Number
Corresponding Author	Fang Zhang, MD, Chief Doctor, Professor, Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, No. 717 Jinbu Street, Muping District, Yantai 264000, Shandong Province, China. zhangfang820127@163.com
Key Words	Hepatocellular carcinoma; Ring finger and WD repeat domain 3; Immune cell infiltration; Bioinformatics
Core Tip	We discovered that ring finger and WD repeat domain 3 (RFWD3) expression is remarkable higher in tumor group than in the corresponding normal group, whether in unpaired or paired hepatocellular carcinoma (HCC) tissues. RFWD3 expression has a significant correlation with the infiltration level of 14 immune cells. Besides, univariate cyclooxygenase regression analysis indicated that RFWD3 is an independent prognostic element in HCC. RFWD3 has the ability to accurately predict the prognosis in HCC.
Publish Date	2023-01-16 06:02
Citation	Miao YD, Quan WX, Wang JT, Gan J, Dong X, Zhang F. Prognostic role of ring finger and WD repeat domain 3 and immune cell infiltration in hepatocellular carcinoma. World J Hepatol 2023; 15(1): 116-122
URL	https://www.wjgnet.com/1948-5182/full/v15/i1/116.htm
DOI	https://dx.doi.org/10.4254/wjh.v15.i1.116

Full Article (PDF)	WJH-15-116.pdf
Full Article (Word)	WJH-15-116.docx
Manuscript File	80909_Auto_Edited-YXX-JLW.docx
Answering Reviewers	80909-Answering reviewers.pdf
Audio Core Tip	80909-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	80909-Conflict-of-interest statement.pdf
Copyright License Agreement	80909-Copyright license agreement.pdf
Peer-review Report	80909-Peer-review(s).pdf
Scientific Misconduct Check	80909-Bing Xing YX-2.png
Scientific Editor Work List	80909-Scientific editor work list.pdf