| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
BMI-1 activates hepatic stellate cells to promote the epithelial-mesenchymal transition of colorectal cancer cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhong-Yang Jiang, Xi-Mei Ma, Xiao-Hui Luan, Zhen-Yu Liuyang, Yi-Yang Hong, Yuan Dai, Qing-Hua Dong and Guan-Yu Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81472213 |
| The Health Commission of Zhejiang Province |
2019ZD010 |
| The Health Commission of Zhejiang Province |
2019ZD029 |
| The Science Technology Department of Zhejiang Province |
LGF20H220001 |
| The Zhejiang Provincial Administration of Traditional Chinese Medicine |
2021ZA088 |
|
| Corresponding Author |
Guan-Yu Wang, MD, PhD, Surgeon, Department of Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. wangguanyu@zju.edu.cn |
| Key Words |
BMI-1; Hepatic stellate cells; Colorectal cancer; Liver metastasis; Epithelial-mesenchymal transition |
| Core Tip |
This study revealed that BMI-1 was upregulated in liver cells during colorectal cancer (CRC) liver metastasis. BMI-1-activated LX2 hepatic stellate cells (HSCs) promoted CRC cell proliferation, migration, and the epithelial-mesenchymal transition both in vitro and in vivo. Mechanistically, transforming growth factor beta 1 was increased in BMI-1 overexpressed LX2 HSCs, and triggered the phosphorylation of downstream SMAD2/3 in CRC cells and the interaction of activated HSCs and CRC cells, thereby further promoting CRC progression. |
| Publish Date |
2023-06-16 09:52 |
| Citation |
Jiang ZY, Ma XM, Luan XH, Liuyang ZY, Hong YY, Dai Y, Dong QH, Wang GY. BMI-1 activates hepatic stellate cells to promote the epithelial-mesenchymal transition of colorectal cancer cells. World J Gastroenterol 2023; 29(23): 3606-3621 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i23/3606.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i23.3606 |
