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2/21/2023 6:19:16 AM | Browse: 197 | Download: 732
Publication Name World Journal of Gastroenterology
Manuscript ID 81153
Country Lithuania
Received
2022-10-27 11:58
Peer-Review Started
2022-10-27 12:00
To Make the First Decision
Return for Revision
2022-11-14 08:44
Revised
2022-11-19 13:10
Second Decision
2022-12-20 08:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-12-21 07:25
Articles in Press
2022-12-21 07:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-12-26 01:58
Publish the Manuscript Online
2023-02-21 06:19
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Control Study
Article Title Comparison of genomic and transcriptional microbiome analysis in gastric cancer patients and healthy individuals
Manuscript Source Unsolicited Manuscript
All Author List Darja Nikitina, Konrad Lehr, Ramiro Vilchez-Vargas, Laimas Virginijus Jonaitis, Mindaugas Urba, Juozas Kupcinskas, Jurgita Skieceviciene and Alexander Link
ORCID
Author(s) ORCID Number
Darja Nikitina http://orcid.org/0000-0002-9942-5118
Konrad Lehr http://orcid.org/0000-0003-3213-8138
Ramiro Vilchez-Vargas http://orcid.org/0000-0001-6535-8212
Laimas Virginijus Jonaitis http://orcid.org/0000-0001-9086-3675
Mindaugas Urba http://orcid.org/0000-0003-0910-9072
Juozas Kupcinskas http://orcid.org/0000-0002-8760-7416
Jurgita Skieceviciene http://orcid.org/0000-0002-4893-6612
Alexander Link http://orcid.org/0000-0002-9514-4562
Funding Agency and Grant Number
Funding Agency Grant Number
European Social Fund 09.3.3-LMT-K-712-01 0130
“Autonomy in old Age” research group ZS/2018/11/95324
Corresponding Author Jurgita Skieceviciene, PhD, Professor, Senior Researcher, Institute for Digestive Research, Lithuanian University of Health Sciences, Eivenių g. 4, Kaunas 44307, Lithuania. jurgita.skieceviciene@lsmu.lt
Key Words Gastric cancer; Microbiome; Helicobacter pylori; 16S rRNA gene; 16S rRNA transcript; 16S rDNA
Core Tip In this study, we aimed to characterize the microbiota of gastric cancer (GC) on two levels: 16S rRNA gene and its transcript. Our study showed that only a small portion of bacterial sequences overlapped using those two approaches. Moreover, our study revealed that obtained results comparing the case group with the controls depend on the chosen modality. We also showed that Reyranella and Sediminibacterium was associated with the Lauren classification and RNA level was more sensitive to detect low abundant bacteria. This study provides novel insights into microbiome study as well as new founding related to complex GC pathogenesis.
Publish Date 2023-02-21 06:19
Citation Nikitina D, Lehr K, Vilchez-Vargas R, Jonaitis LV, Urba M, Kupcinskas J, Skieceviciene J, Link A. Comparison of genomic and transcriptional microbiome analysis in gastric cancer patients and healthy individuals. World J Gastroenterol 2022; 29(7): 1202-1218
URL https://www.wjgnet.com/1007-9327/full/v29/i7/1202.htm
DOI https://dx.doi.org/10.3748/wjg.v29.i7.1202
Full Article (PDF) WJG-29-1202.pdf
Full Article (Word) WJG-29-1202.docx
STROBE Statement 81153-STROBE-Statement-revision.pdf
Manuscript File 81153_Auto_Edited-JLW.docx
Answering Reviewers 81153-Answering reviewers.pdf
Audio Core Tip 81153-Audio core tip.mp3
Biostatistics Review Certificate 81153-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 81153-Conflict-of-interest statement.pdf
Copyright License Agreement 81153-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 81153-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 81153-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 81153-Institutional review board statement.PDF
Non-Native Speakers of English Editing Certificate 81153-Language certificate.pdf
Supplementary Material 81153-Supplementary material.pdf
Peer-review Report 81153-Peer-review(s).pdf
Scientific Misconduct Check 81153-Bing-Wang JJ-2.png
Scientific Editor Work List 81153-Scientific editor work list.pdf