| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi Zheng, Feng Cao, Yi-Xuan Ding, Jiong-Di Lu, Yuan-Qiao Fu, Lin Liu, Yu-Lin Guo, Shuang Liu, Hai-Chen Sun, Ye-Qing Cui and Fei Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Beijing Municipal Science and Technology Commission, Capital Research and Demonstration Application of Clinical Diagnosis and Treatment Technology |
Z191100006619038 |
| The Beijing Municipal Science and Technology Commission, Capital Research and Demonstration Application of Clinical Diagnosis and Treatment Technology |
Z171100001017077 |
| The Capital Health Research and Development of Special |
2020-1-2012 |
|
| Corresponding Author |
Fei Li, MD, PhD, Deputy Director, Professor, Surgeon, Department of General Surgery, Xuanwu Hospital, Capital Medical University, No. 45 Chang-chun Street, Xi-Cheng District
, Beijing 100053, China. feili36@ccmu.edu.cn |
| Key Words |
Acute pancreatitis; Exosome; miR-125b-5p; Macrophage; Mechanism |
| Core Tip |
Our study confirmed that miR-125b-5p can promote the inflammatory response of acute pancreatitis (AP), and its potential targets were found via RNA sequencing assay. However, the likely mechanism remains unclear. Consequently, our study intends to elucidate the molecular mechanism of exosome-derived miR-125b-5p in promoting AP exacerbation from the perspective of the interaction between immune cells and acinar cells. |
| Publish Date |
2023-04-23 08:02 |
| Citation |
Zheng Z, Cao F, Ding YX, Lu JD, Fu YQ, Liu L, Guo YL, Liu S, Sun HC, Cui YQ, Li F. Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway. World J Gastrointest Surg 2023; 15(4): 600-620 |
| URL |
https://www.wjgnet.com/1948-9366/full/v15/i4/600.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v15.i4.600 |
