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Articles Published Processes
2/28/2023 11:21:21 AM | Browse: 414 | Download: 1526
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Received |
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2022-11-03 04:38 |
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Peer-Review Started |
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2022-11-03 04:41 |
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First Decision by Editorial Office Director |
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2022-11-14 06:48 |
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Return for Revision |
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2022-11-14 06:48 |
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Revised |
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2022-11-22 16:36 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-02-13 04:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-02-16 18:02 |
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Articles in Press |
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2023-02-16 18:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-02-23 06:18 |
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Publish the Manuscript Online |
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2023-02-28 11:21 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Stress granules inhibit endoplasmic reticulum stress-mediated apoptosis during hypoxia-induced injury in acute liver failure
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Yuan Li, Fan Yang, Xun Li, Lu-Wen Wang and Yao Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82100630 |
| National Natural Science Foundation of China |
82100894 |
| Fundamental Research Funds for the Central Universities |
2042021kf0080 |
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| Corresponding Author |
Yao Wang, Doctor, Chief Physician, Department of Infectious Diseases, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuhan 430060, Hubei Province, China. rm003743@whu.edu.cn |
| Key Words |
Acute liver failure; Stress granules; Hypoxia; Endoplasmic reticulum stress; Apoptosis |
| Core Tip |
Hepatocytes were damaged by hypoxia and ischemia injury in the process of acute liver failure. At this time, the content of HIF-1α in cells increased, which inhibited the formation of stress granules (SGs) mediated by G3BP1 and promoted the expression of endoplasmic reticulum stress (ERS) marker molecules activating transcription factor 4 (ATF4) and CCAAT/enhancer-binding protein-homologous protein. The activated ERS pathway further promotes hepatocyte apoptosis. Promoting SGs synthesis can inhibit the level of hepatocyte apoptosis by inhibiting the ATF4-mediated ERS pathway. |
| Publish Date |
2023-02-28 11:21 |
| Citation |
Li WY, Yang F, Li X, Wang LW, Wang Y. Stress granules inhibit endoplasmic reticulum stress-mediated apoptosis during hypoxia-induced injury in acute liver failure. World J Gastroenterol 2023; 29(8): 1315-1329 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i8/1315.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i8.1315 |
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