Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	8137
Country	United States

Received	2013-12-18 09:06
Peer-Review Started	2013-12-18 16:10
To Make the First Decision	2014-02-27 11:27
Return for Revision	2014-03-05 09:38
Revised	2014-03-19 03:57
Second Decision	2014-05-08 17:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-08 18:03
Articles in Press	2014-05-23 12:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-01 19:06
Publish the Manuscript Online	2014-07-15 13:33

ISSN	1948-5204 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Genotypic characteristics of resistant tumors to pre-operative ionizing radiation in rectal cancer
Manuscript Source	Invited Manuscript
All Author List	Zeeshan Ramzan, Ammar B Nassri and Sergio Huerta
Funding Agency and Grant Number
Corresponding Author	Zeeshan Ramzan, MD, Assistant Professor, VA North Texas Healthcare System-Dallas VA Medical Center, University of Texas Southwestern Medical Center, 4500 S. Lancaster Road, Dallas, TX 75216, United States. zeeshanramzan@hotmail.com
Key Words	Ionizing radiation; DNA double-strand break; Non-homologous end-joining pathway; DNA-PKcs; Ku proteins; Complete pathological response; Radiation therapy; Apoptosis; Angiogenesis
Core Tip	Treatment of locally advanced rectal cancer stage II and III includes neoadjuvant chemo-radiation followed by surgery if clinically feasible. A strategy of observing patients without an operation has been proposed by some surgeons, but this is still the center of much debate. Moreover, the therapeutic effect of ionizing radiation in treatment of rectal cancer varies significantly from one person to another. This has led investigators to identify the molecular targets and pathways in rectal tumors resistant to ionizing radiation in a bid to improve the therapeutic effect of radiation by advanced biomedical and genetic engineering.
Publish Date	2014-07-15 13:33
Citation	Ramzan Z, Nassri AB, Huerta S. Genotypic characteristics of resistant tumors to pre-operative ionizing radiation in rectal cancer. World J Gastrointest Oncol 2014; 6(7): 194-210
URL	http://www.wjgnet.com/1948-5204/full/v6/i7/194.htm
DOI	http://dx.doi.org/10.4251/wjgo.v6.i7.194

Full Article (PDF)	WJGO-6-194.pdf
Full Article (Word)	WJGO-6-194.doc
Manuscript File	8137-Review.docx
Answering Reviewers	8137-Answering reviewers.pdf
Copyright License Agreement	8137-Copyright assignment.pdf
Peer-review Report	8137-Peer review(s).pdf
Scientific Editor Work List	8137-Scientific editor work list.pdf