Publication Name	World Journal of Clinical Cases
Manuscript ID	81390
Country	China

Received	2022-11-07 13:09
Peer-Review Started	2022-11-07 13:11
To Make the First Decision
Return for Revision	2022-11-25 02:23
Revised	2022-12-02 12:01
Second Decision	2023-02-08 03:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-02-08 08:16
Articles in Press	2023-02-08 08:16
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-02-18 19:35
Typeset the Manuscript	2023-02-28 01:12
Publish the Manuscript Online	2023-03-07 08:12

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Hematology
Manuscript Type	Case Report
Article Title	Glucocorticoid-induced thrombotic microangiopathy in paroxysmal nocturnal hemoglobinuria: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Dong Yang, Bo Ju, Jia Xu, Nuan-Nuan Xiu, Xiao-Yun Sun and Xi-Chen Zhao
ORCID	Author(s) ORCID Number Xiao-Dong Yang http://orcid.org/0000-0001-6754-9004 Bo Ju http://orcid.org/0000-0003-1610-8481 Jia Xu http://orcid.org/0000-0002-2444-8980 Nuan-Nuan Xiu http://orcid.org/0000-0003-4369-0147 Xiao-Yun Sun http://orcid.org/0000-0002-4667-9974 Xi-Chen Zhao http://orcid.org/0000-0002-3304-2851
Funding Agency and Grant Number	Funding Agency Grant Number Specialized Scientific Research Fund Projects of The Medical Group of Qingdao University No: YLJT20201002
Corresponding Author	Xi-Chen Zhao, MD, Chief Physician, Department of Hematology, The Central Hospital of Qingdao West Coast New Area, No. 9 Huangpujiang Road, Qingdao 266555, Shandong Province, China. zhaoxichen2003@163.com
Key Words	Aplastic anemia; Paroxysmal nocturnal hemoglobinuria; Glucocorticoid; Methylprednisolone; Thrombotic microangiopathy; Platelet transfusion refractoriness; Case report
Core Tip	Glucocorticoid-associated thrombotic microangiopathy has rarely been reported. Here, we report a patient with paroxysmal nocturnal hemoglobinuria whose hematological parameters worsened during methylprednisolone treatment, and increasing methylprednisolone doses further exacerbated the cytopenia. Observation of platelet transfusion refractoriness suggested the possibility of thrombotic microangiopathy development. Significant hematological improvement was achieved after discontinuation of methylprednisolone treatment, confirming that methylprednisolone treatment acted as the triggering factor to promote platelet aggregation within the microcirculation. Given the wide use of glucocorticoids in clinical practice and the high incidence of thrombocytopenia during glucocorticoid treatment, particular attention should be given to this potentially fatal complication.
Publish Date	2023-03-07 08:12
Citation	Yang XD, Ju B, Xu J, Xiu NN, Sun XY, Zhao XC. Glucocorticoid-induced thrombotic microangiopathy in paroxysmal nocturnal hemoglobinuria: A case report and review of literature. World J Clin Cases 2023; 11(8): 1799-1807
URL	https://www.wjgnet.com/2307-8960/full/v11/i8/1799.htm
DOI	https://dx.doi.org/10.12998/wjcc.v11.i8.1799

Full Article (PDF)	WJCC-11-1799.pdf
Full Article (Word)	WJCC-11-1799.docx
Manuscript File	81390-Review-Filipodia.docx
Answering Reviewers	81390-Answering reviewers.pdf
Audio Core Tip	81390-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	81390-Conflict-of-interest statement.pdf
Copyright License Agreement	81390-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	81390-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	81390-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	81390-Language certificate.pdf
Peer-review Report	81390-Peer-review(s).pdf
Scientific Misconduct Check	81390-Bing-Ma YJ-2.jpg
Scientific Editor Work List	81390-Scientific editor work list.pdf