| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Better performance of PIVKA-II for detecting hepatocellular carcinoma in patients with chronic liver disease with normal total bilirubin
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiang-Jun Qian, Zhu-Mei Wen, Xiao-Ming Huang, Hui-Juan Feng, Shan-Shan Lin, Yan-Na Liu, Sheng-Cong Li, Yu Zhang, Wen-Guang Peng, Jia-Rui Yang, Zhe-Yu Zheng, Lei Zhang, Da-Wei Zhang, Feng-Min Lu, Li-Juan Liu and Wei-Dong Pan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Clinical Discipline, Fuzhou “14th Five-Year Plan” Clinical Key Specialty (laboratory medicine) and the National Science Foundation of China |
No. 82002587 |
|
| Corresponding Author |
Wei-Dong Pan, MD, Doctor, Professor, Surgeon, Department of Pancreatic Hepatobiliary Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, No. 26 Erheng Road, Tianhe District, Guangzhou 510655, Guangdong Province, China. panwd@mail.sysu.edu.cn |
| Key Words |
Protein induced by vitamin K absence or antagonist-II; Chronic liver disease; Total bilirubin; Hepatocellular carcinoma; Diagnosis; Hepatitis B virus |
| Core Tip |
This study demonstrated that elevated serum protein induced by vitamin K absence or antagonist-II (PIVKA-II) were positively associated with serum total bilirubin (TBIL) in patients with chronic liver disease (CLD), and the levels of PIVKA-II in CLD patients with normal serum TBIL were significantly lower than those in CLD patients with abnormal serum TBIL. Serum PIVKA-II has better performance in detecting hepatocellular carcinoma (HCC) at an early stage for CLD patients with normal serum TBIL, which was more prominently perceived in patients with viral etiology and hepatitis B virus alone. These findings may be important for surveillance counseling of early-stage HCC. |
| Publish Date |
2023-02-28 11:21 |
| Citation |
Qian XJ, Wen ZM, Huang XM, Feng HJ, Lin SS, Liu YN, Li SC, Zhang Y, Peng WG, Yang JR, Zheng ZY, Zhang L, Zhang DW, Lu FM, Liu LJ, Pan WD. Better performance of PIVKA-II for detecting hepatocellular carcinoma in patients with chronic liver disease with normal total bilirubin. World J Gastroenterol 2023; 29(8): 1359-1373 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i8/1359.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i8.1359 |
