Publication Name	World Journal of Cardiology
Manuscript ID	8142
Country	Oman

Received	2013-12-18 10:11
Peer-Review Started	2013-12-18 15:47
To Make the First Decision	2014-01-16 08:31
Return for Revision	2014-01-26 16:20
Revised	2014-01-29 03:48
Second Decision	2014-06-16 13:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-16 14:04
Articles in Press	2014-06-16 14:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-28 13:58
Publish the Manuscript Online	2014-09-17 14:32

ISSN	1949-8462 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Topic Highlights
Article Title	Prehypertension: Underlying pathology and therapeutic options
Manuscript Source	Invited Manuscript
All Author List	Sulayma Albarwani, Sultan Al-Siyabi and Musbah O Tanira
Funding Agency and Grant Number
Corresponding Author	Dr. Sulayma Albarwani, Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O.Box 35, Muscat 123, Oman. salbarwani@squ.edu.om
Key Words	Prehypertension; Renin-angiotensin system; Therapeutic lifestyle changes; Polypill
Core Tip	There is a current debate over the ideal means of intervening in prehypertension. Since it is the cardiovascular risk that constitute the basis for intervention in both prehypertension and hypertension, the review discusses the following points, that: (1) categorizing blood pressure levels is based on mere 20 mmHg brackets; hence this doctrine may be re-visited to include other cardiovascular risk factors to categorize patients regardless of their blood pressure level; (2) investigating the therapeutic potential of intervening in all pathophysiological processes associated with prehypertension; and (3) ascertaining the therapeutic value of the “Polypill” in prehypertensives as means of primary prevention.
Publish Date	2014-09-17 14:32
Citation	Albarwani S, Al-Siyabi S, Tanira MO. Prehypertension: Underlying pathology and therapeutic options. World J Cardiol 2014; 6(8): 728-743
URL	http://www.wjgnet.com/1949-8462/full/v6/i8/728.htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i8.728

Full Article (PDF)	WJC-6-728.pdf
Full Article (Word)	WJC-6-728.doc
Manuscript File	8142-Review.docx
Answering Reviewers	8142-Answering reviewers.pdf
Copyright License Agreement	8142-Copyright assignment.pdf
Peer-review Report	8142-Peer review(s).pdf
Scientific Misconduct Check	8142-CrossCheck.jpg
Scientific Editor Work List	8142-Scientific editor work list.pdf