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Articles Published Processes
2/24/2023 9:09:48 AM | Browse: 201 | Download: 411
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Received |
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2022-11-10 13:34 |
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Peer-Review Started |
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2022-11-10 13:36 |
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To Make the First Decision |
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Return for Revision |
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2022-12-13 09:56 |
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Revised |
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2022-12-26 13:56 |
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Second Decision |
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2023-02-07 03:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-02-07 07:05 |
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Articles in Press |
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2023-02-07 07:05 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-01-13 02:41 |
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Typeset the Manuscript |
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2023-02-08 08:39 |
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Publish the Manuscript Online |
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2023-02-24 09:09 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dermatology |
| Manuscript Type |
Case Report |
| Article Title |
Hidrotic ectodermal dysplasia in a Chinese pedigree: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming-Yi Liao, Hui Peng, Long-Nian Li, Tao Yang, Shi-Yin Xiong and Xiao-Ying Ye |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao-Ying Ye, Doctor, Chief Physician, Professor, Department of Dermatology, First Affiliated Hospital of Gannan Medical University, No. 23 Qingnian Road, Zhanggong District, Ganzhou 341000, Jiangxi Province, China. 13870768166@139.com |
| Key Words |
Hidrotic ectodermal dysplasia; GJB6; Connexin; Gene sequencing; Cell transfection; Case report |
| Core Tip |
We report on a Chinese family with hidrotic ectodermal dysplasia (HED), with patients in the family presenting varying degrees of hair dysplasia, nail dysplasia, and palmoplantar hyperkeratosis. In addition, we performed a literature review of other reported HED genotypes and their corresponding phenotypes, which lays a foundation for subsequent studies on these associations. Overexpression vectors of the GJB6 gene and its variants (variation sites: c.31G>A, c.263C>T, c.110T>A) were established and transfected into a HaCaT cell model. The expression changes of related mRNA and proteins before and after gene editing were obtained by real-time reverse transcriptase-polymerase chain reaction and Western blot, respectively, to provide clues for subsequent pathogenesis studies. |
| Publish Date |
2023-02-24 09:09 |
| Citation |
Liao MY, Peng H, Li LN, Yang T, Xiong SY, Ye XY. Hidrotic ectodermal dysplasia in a Chinese pedigree: A case report. World J Clin Cases 2023; 11(6): 1403-1409 |
| URL |
https://www.wjgnet.com/2307-8960/full/v11/i6/1403.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i6.1403 |
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